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Titolo:
INTERLEUKIN-12 - AN IMMUNOREGULATORY CYTOKINE PRODUCED BY B-CELLS ANDANTIGEN-PRESENTING CELLS
Autore:
SARTORI A; MA XJ; GRI G; SHOWE L; BENJAMIN D; TRINCHIERI G;
Indirizzi:
UNIV PENN,SCH MED,WISTAR INST ANAT & BIOL,3601 SPRUCE ST PHILADELPHIAPA 19104 OHIO STATE UNIV,DIV HEMATOL & ONCOL,ARTHUR G JAMES CANC HOSP & RES INST COLUMBUS OH 43210
Titolo Testata:
Methods
fascicolo: 1, volume: 11, anno: 1997,
pagine: 116 - 127
SICI:
1046-2023(1997)11:1<116:I-AICP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA-PRODUCTION; BLOOD MONONUCLEAR-CELLS; NECROSIS-FACTOR-ALPHA; LYMPHOCYTE MATURATION FACTOR; STIMULATORY FACTOR INTERLEUKIN-12; ACTIVATED HUMAN LYMPHOBLASTS; VIRUS-INFECTED PATIENTS; CD4(+) T-CELLS; IMMUNE-RESPONSES; IL-12 RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
102
Recensione:
Indirizzi per estratti:
Citazione:
A. Sartori et al., "INTERLEUKIN-12 - AN IMMUNOREGULATORY CYTOKINE PRODUCED BY B-CELLS ANDANTIGEN-PRESENTING CELLS", Methods, 11(1), 1997, pp. 116-127

Abstract

Interleukin 12 (IL-12) is a heterodimeric protein produced by B cells, phagocytic cells, and other antigen-presenting cells. IL-12 was originally purified from the supernatant fluids of human EBV-transformed cell lines and later observed to be produced by the large majority of such cell lines, especially and at high levels from those derived from AIDS-associated lymphomas. However, phagocytic cells rather than B cells appear to be the most important physiological producers of IL-12. There are two pathways of IL-12 induction in phagocytic cells: a T-cell-independent one, induced primarily by bacteria, bacterial products, or intracellular parasites and important in the early inflammatory response of innate resistance; and a T-cell-dependent one, induced by the interaction of CD40L on activated T cells with CD40 receptor on IL-12-producing cells (phagocytic cells and antigen-presenting cells) and important in the regulation of adaptive immunity. IL-12 induces production of cytokines, especially interferon-gamma, from both T and NK cells, enhances the cytotoxic activity of NK cells and the generation of cytotoxic T cells, and has a proliferative activity on T and NK cells. Both in vivo and in vitro, IL-12 is a powerful inducer of T helper type1 (Th1) response, whereas it inhibits Th2-type responses. (C) 1997 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:46:50