Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INDUCTION OF FREE-RADICALS IN THE COCHLEA BY AN AMINOGLYCOSIDE ANTIBIOTIC
Autore:
TAKAYAMA M; YAMANE H; KONISHI K; IGUCHI H; SHIBATA S; SUNAMI K; NAKAI Y; NAKAGAWA T;
Indirizzi:
OSAKA CITY UNIV,SCH MED,DEPT OTOLARYNGOL,ABENO KU,1-5-7 ASAHI MACHI OSAKA 545 JAPAN YODOGAWA CHRISTIANS HOSP OSAKA JAPAN
Titolo Testata:
Acta oto-laryngologica
, , anno: 1997, supplemento:, 528
pagine: 19 - 24
SICI:
0001-6489(1997):<19:IOFITC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED OTOTOXICITY; DAMAGE;
Keywords:
KANAMYCIN; INNER EAR; SUPEROXIDE; CE METHOD; OTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
M. Takayama et al., "INDUCTION OF FREE-RADICALS IN THE COCHLEA BY AN AMINOGLYCOSIDE ANTIBIOTIC", Acta oto-laryngologica, 1997, pp. 19-24

Abstract

Free radicals are known to cause damage to biological tissues. We used histochemical methods to examine the emergence of free radicals in kanamycin (KM)-treated guinea pig cochlea. As a preliminary in vitro study, the emergence of free radicals was observed in guinea pig cochleaincubated with KM. In an in vivo study, KM was placed on the guinea pig round window membrane and the emergence of free radicals was observed over time. The emergence of free radicals was observed along the luminal membrane and hair bundles of outer hair cells. The appearance and disappearance of free radicals in the cochlea coincided with the transport of KM into the inner ear. These findings suggest that the emergence of free radicals could be attributed to the administration of KM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:02:02