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Titolo:
TO THE GENETIC RISK AFTER HIGH-DOSE RADIO IODINE THERAPY WITH REGARD TO THE GONADAL DOSE
Autore:
EHRENHEIM C; HAUSWIRTH C; FITSCHEN J; MARTIN E; GETTING G; HUNDESHAGEN H;
Indirizzi:
HANNOVER MED SCH,ABT NUKL MED & SPEZIELLE BIOPHYS,CARL NEUBERG STR 1 D-30623 HANNOVER GERMANY
Titolo Testata:
Nuklearmedizin
fascicolo: 5, volume: 36, anno: 1997,
pagine: 157 - 166
Fonte:
ISI
Lingua:
GER
Soggetto:
DIFFERENTIATED THYROID-CANCER; I-131; PREGNANCY;
Keywords:
HIGH DOSE RADIOIODINE THERAPY; GONADAL DOSE; PREGNANCY; GENETIC RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C. Ehrenheim et al., "TO THE GENETIC RISK AFTER HIGH-DOSE RADIO IODINE THERAPY WITH REGARD TO THE GONADAL DOSE", Nuklearmedizin, 36(5), 1997, pp. 157-166

Abstract

Aim: The genetic risk for the offspring of patients treated with highdoses of radioiodine was to be assessed with special regard to the gonadal dose caused by diagnostic and therapeutic procedures. Methods: 41 young females (aged between 19 and 39 years) and four young males (aged 26 to 36 years) treated with radioiodine because of a thyroid carcinoma were interviewed by use of a questionnaire. The course of pregnancy and birth history could be documented as well as the congenital and developmental conditions of 56 children. Results: The amount of radioactivity applied for therapy and whole body scans ranged over 4,144 and 35,15 GBq I-131; the individual gonadal dose was calculated based on the MIRD model and ranged over 0,2 and 2,2 Sv (0,51 Sv at a mean). The period of time between the last radioiodine application and confinement was at least 9 months, not exceeding 14 years. As to the course of pregnancy and birth two early abortions, one extrauterine gravidity acid one premature birth due to an insufficiency of the placenta were stared. In one case a chromosomal translocation 7/14 occured as a genetic defect which lead to an interruption. The children's development was unconspicuous except of two cases of neurodermatitis as well as multiple allergies and an early closure of the anterior fontanelle in onechild each. Conclusion: Although the genetic risk is supposed to increase with the gonadal dose achieved (doubling dose 1 Sv) and the increased risk of any congenital anomaly was calculated as about 13% at a mean in our patients, the rate of genetic determined diseases was not elevated (1,8% or 1/57). Thus, no increase of genetic defects or congenital malformations was reported in a total of 408 children described in the literature and in our group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:41:30