Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INTERACTION OF MYCOBACTERIUM-AVIUM WITH ENVIRONMENTAL AMEBAS ENHANCESVIRULENCE
Autore:
CIRILLO JD; FALKOW S; TOMPKINS LS; BERMUDEZ LE;
Indirizzi:
CALIF PACIFIC MED CTR,KUZELL INST ARTHRITIS & INFECT DIS,2330 CLAY ST,ROOM 201 SAN FRANCISCO CA 94115 CALIF PACIFIC MED CTR,KUZELL INST ARTHRITIS & INFECT DIS SAN FRANCISCO CA 94115 STANFORD UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL STANFORD CA 94305
Titolo Testata:
Infection and immunity
fascicolo: 9, volume: 65, anno: 1997,
pagine: 3759 - 3767
SICI:
0019-9567(1997)65:9<3759:IOMWEA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHAGOSOME-LYSOSOME FUSION; HEP-2 EPITHELIAL-CELLS; FREE-LIVING AMEBAS; LEGIONELLA-PNEUMOPHILA; ACANTHAMOEBA-CASTELLANII; LEGIONNAIRES-DISEASE; INTRACELLULAR GROWTH; POTABLE WATER; LISTERIA-MONOCYTOGENES; DISSEMINATED INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Cirillo et al., "INTERACTION OF MYCOBACTERIUM-AVIUM WITH ENVIRONMENTAL AMEBAS ENHANCESVIRULENCE", Infection and immunity, 65(9), 1997, pp. 3759-3767

Abstract

Environmental mycobacteria are a common cause of human infections, Recently, contaminated domestic water supplies have been suggested as a potential environmental source of several mycobacterial diseases, Since many of these mycobacterial species replicate best intracellularly, environmental hosts have been sought, In the present study, we examined the interaction of Mycobacterium avium with a potential protozoan host, the water-borne amoeba Acanthamoeba castellanii. We found that M. avium enters and replicates in A. castellanii. In addition, similar tothat shown for mycobacteria within macrophages, M. avium inhibits lysosomal fusion and replicates in vacuoles that are tightly juxtaposed to the bacterial surfaces within amoebae. In order to determine whethergrowth of M. avium in amoebae plays a role in human infections, we tested the effects of this growth condition on virulence, We found that growth of M. avium in amoebae enhances both entry and intracellular replication compared to growth of bacteria in broth, Furthermore, amoeba-grown M. avium was also more virulent in the beige mouse model of infection. These data suggest a role for protozoa present in water environments as hosts for pathogenic mycobacteria, particularly M. avium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:20:27