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Titolo:
ISLET AMYLOID POLYPEPTIDE IN THE GUT AND PANCREAS - LOCALIZATION, ONTOGENY AND GUT MOTILITY EFFECTS
Autore:
MULDER H; EKELUND M; EKBLAD E; SUNDLER F;
Indirizzi:
UNIV LUND HOSP,DEPT PHYSIOL & NEUROSCI,SECT NEUROENDOCRINE CELL BIOL,E BLOCKET S-22185 LUND SWEDEN
Titolo Testata:
Peptides
fascicolo: 6, volume: 18, anno: 1997,
pagine: 771 - 783
SICI:
0196-9781(1997)18:6<771:IAPITG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; HUMAN FETAL PANCREAS; GASTROINTESTINAL-TRACT; ENDOCRINE PANCREAS; RAT AMYLIN; CELLS; EXPRESSION; INSULIN; MOUSE; IAPP;
Keywords:
ISLET AMYLOID POLYPEPTIDE; AMYLIN; GASTROINTESTINAL TRACT; PANCREAS; EMBRYONIC DEVELOPMENT; IMMUNOCYTOCHEMISTRY; GUT RELAXATION; NEUROMODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
H. Mulder et al., "ISLET AMYLOID POLYPEPTIDE IN THE GUT AND PANCREAS - LOCALIZATION, ONTOGENY AND GUT MOTILITY EFFECTS", Peptides, 18(6), 1997, pp. 771-783

Abstract

The occurrence of islet amyloid polypeptide (IAPP) in the gut and pancreas of several species and during ontogeny of the rat, was studied using immunocytochemistry. Effects of IAPP on rat ileal smooth muscle were assessed in vitro. Islets of most, but not all, species examined, displayed IAPP in insulin cells and, in some species, also in somatostatin-and peptide YY (PYY)-containing cells. In the gut, expression of IAPP varied among species; when present, IAPP was most abundant in theproximal part and co-localized with somatostatin, PYY, gastrin/cholecystokinin, enteroglucagon or serotonin. IAPP was first demonstrated atembryonic day 12 and 16 in islet and gastrointestinal endocrine cells, respectively. IAPP relaxed grit muscle and reduced electrical field stimulation-evoked contractions, presumably by inhibiting acetylcholine release. Thus, IAPP expression in islets is consistent with an important role for IAPP in fuel metabolism; the gastrointestinal expressionand motor effects of IAPP suggest that IAPP may modulate gastrointestinal function. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:35:22