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Titolo:
EFFECTS OF AUTOANTIBODIES ON THE COURSE OF PREGNANCY AND FETAL GROWTH
Autore:
IIJIMA T; TADA H; HIDAKA Y; MITSUDA N; MURATA Y; AMINO N;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT LAB MED,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT LAB MED SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT OBSTET & GYNECOL SUITA OSAKA 565 JAPAN
Titolo Testata:
Obstetrics and gynecology
fascicolo: 3, volume: 90, anno: 1997,
pagine: 364 - 369
SICI:
0029-7844(1997)90:3<364:EOAOTC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECURRENT SPONTANEOUS-ABORTION; ANTIPHOSPHOLIPID ANTIBODIES; ANTITHYROID ANTIBODIES; ANTICARDIOLIPIN ANTIBODIES; THYROID ABNORMALITIES; LUPUS ANTICOAGULANT; SEVERE PREECLAMPSIA; HABITUAL ABORTION; NONPREGNANT WOMEN; ANTINUCLEAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T. Iijima et al., "EFFECTS OF AUTOANTIBODIES ON THE COURSE OF PREGNANCY AND FETAL GROWTH", Obstetrics and gynecology, 90(3), 1997, pp. 364-369

Abstract

Objective: To assess the effects of autoantibodies on the course of pregnancy and fetal growth. Methods: One thousand one hundred seventy-nine healthy women with singleton gestations were screened in early pregnancy for seven kinds of autoantibodies: antithyroid microsomal antibody, antithyroglobulin antibody, two kinds of rheumatoid factor, antinuclear antibody, anti-DNA antibody, and antimitochondrial antibody. Results: In 228 cases (19.3%), at least one autoantibody was found; however, overlap of autoantibodies in the same individual was unexpectedlyrare, and only two cases were positive for as many as four autoantibodies. A significantly higher rate of spontaneous abortion was observedin antibody-positive subjects, especially those with antithyroid microsomal (10.4%) or antinuclear antibodies (16.0%), compared with all antibody-negative subjects (5.5%). There were no significant differencesin any outcome assessed among subjects positive for antithyroglobulinantibody, anti-DNA antibody, or antimitochondrial antibody compared with all antibody-negative subjects. None of the seven autoantibodies affected the rates of preterm delivery, stillbirth, pregnancy-induced hypertension, malformation, or gender ratio. Conclusion: Antithyroid microsomal antibody and antinuclear antibody are the only autoantibodiesthat increase the abortion rate. (C) 1997 by The American College of Obstetricians and Gynecologists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:40:34