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Titolo:
METABOLIC ANDROGENIZATION OF FEMALE DAPHNIA-MAGNA BY THE XENOESTROGEN4-NONYLPHENOL
Autore:
BALDWIN WS; GRAHAM SE; SHEA D; LEBLANC GA;
Indirizzi:
N CAROLINA STATE UNIV,DEPT TOXICOL RALEIGH NC 27695 N CAROLINA STATE UNIV,DEPT TOXICOL RALEIGH NC 27695
Titolo Testata:
Environmental toxicology and chemistry
fascicolo: 9, volume: 16, anno: 1997,
pagine: 1905 - 1911
SICI:
0730-7268(1997)16:9<1905:MAOFDB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKYLPHENOL POLYETHOXYLATES; RAT-LIVER; TESTOSTERONE; NONYLPHENOL; IDENTIFICATION; ENVIRONMENT; COMPONENTS; MODULATION; SULFATION; ENZYMES;
Keywords:
4-NONYLPHENOL; ANDROGENIZATION; STEROID METABOLISM; DAPHNIA MAGNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
W.S. Baldwin et al., "METABOLIC ANDROGENIZATION OF FEMALE DAPHNIA-MAGNA BY THE XENOESTROGEN4-NONYLPHENOL", Environmental toxicology and chemistry, 16(9), 1997, pp. 1905-1911

Abstract

Vertebrates and invertebrates metabolize testosterone to a variety ofless-polar derivatives that elicit varying degrees of androgenicity as well as polar elimination products. We have developed a model, usingthe cladoceran Daphnia magna, with which the ability of xenobiotics to alter steroid hormone metabolism can be assessed and possible physiologic consequences evaluated during a 3-week assay. This model was used to assess the effects of the xenoestrogen 4-nonylphenol on steroid-metabolic processes. Exposure of daphnids to 100 mu g/L 4-nonylphenol for 48 h caused a significant increase in the accumulation of radioactivity derived from [C-14]testosterone provided to the exposure media. More definitive analyses demonstrated that both 25 and 100 mu g/L 4-nonylphenol disrupted components of the testosterone metabolic pathway that would lead to a decrease in the metabolic elimination of testosterone and an increase in the accumulation of androgenic derivatives. Exposure of daphnids to 100 mu g/L 4-nonylphenol significantly decreased fecundity of the organisms while having no effect on survival of the parental organisms. Comparison of metabolic and reproductive effects of LC-nonylphenol revealed that 71 mu g/L, the reproductive chronic value, would reduce the metabolic elimination of testosterone by approximately 50%. This relationship is consistent with that which we have reported for other toxicants and identifies a mechanism, in addition to estrogenicity, that may contribute to the reproductive toxicity of this compound.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:16:06