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Titolo:
SUBUNIT COMPOSITION, KINETIC, AND PERMEATION PROPERTIES OF AMPA RECEPTORS IN SINGLE NEOCORTICAL NONPYRAMIDAL CELLS
Autore:
ANGULO MC; LAMBOLEZ B; AUDINAT E; HESTRIN S; ROSSIER J;
Indirizzi:
ECOLE SUPER PHYS & CHIM IND VILLE PARIS,CNRS,UNITE RECH ASSOCIEE 2054,10 RUE VAUQUELIN F-75231 PARIS 5 FRANCE ECOLE SUPER PHYS & CHIM IND VILLE PARIS,CNRS,UNITE RECH ASSOCIEE 2054F-75231 PARIS 5 FRANCE UNIV TENNESSEE,CTR HLTH SCI,DEPT ANAT & NEUROBIOL MEMPHIS TN 38163
Titolo Testata:
The Journal of neuroscience
fascicolo: 17, volume: 17, anno: 1997,
pagine: 6685 - 6696
SICI:
0270-6474(1997)17:17<6685:SCKAPP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-OPERATED CHANNELS; PATCH-CLAMP RECORDINGS; RAT FRONTAL-CORTEX; KAINATE RECEPTORS; CA2+ PERMEABILITY; NEURONS; DESENSITIZATION; RECTIFICATION; BRAIN; DETERMINANT;
Keywords:
AMPA RECEPTOR; NEOCORTEX; INTERNEURON; SINGLE-CELL RT-PCR; FAST GLUTAMATE APPLICATION; SUBUNIT; SPLICING; EDITING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Angulo et al., "SUBUNIT COMPOSITION, KINETIC, AND PERMEATION PROPERTIES OF AMPA RECEPTORS IN SINGLE NEOCORTICAL NONPYRAMIDAL CELLS", The Journal of neuroscience, 17(17), 1997, pp. 6685-6696

Abstract

Native AMPA receptors (AMPARs) were investigated in neocortical fast-spiking (FS) and regular-spiking nonpyramidal (RSNP) cells. The onset of and recovery from desensitization as well as current rectification and single-channel conductance were studied by using fast glutamate application to outside-out patches. The GluR1-4 subunit, flip/flop splicing, and R/G editing expression patterns of functionally characterizedcells were determined by single-cell reverse transcription-PCR to correlate the subunit composition of native AMPARs with their functional properties. Our sample, mostly constituted by RSNP neurons, predominantly expressed GluR3 flip and GluR2 flop. In individual cells, flip/flop splicing of each subunit appeared to be regulated independently, whereas for R/G editing all subunits were either almost fully edited or unedited. We confirmed that the relative GluR2 expression controls the permeation properties of native AMPARs, whereas none of the single molecular

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 11:35:11