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Titolo:
ACETYLCHOLINE-RECEPTOR AUTOANTIBODY SECRETION BY THYMOCYTES - RELATIONSHIP TO MYASTHENIA-GRAVIS
Autore:
YOSKIKAWA H; LENNON VA;
Indirizzi:
MAYO CLIN & MAYO FDN,DEPT IMMUNOL,NEUROIMMUNOL LAB,RM 828,GUGGENHEIM BLDG ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT IMMUNOL,NEUROIMMUNOL LAB ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL,NEUROIMMUNOL LAB ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL,NEUROIMMUNOL LAB ROCHESTERMN 55905
Titolo Testata:
Neurology
fascicolo: 2, volume: 49, anno: 1997,
pagine: 562 - 567
SICI:
0028-3878(1997)49:2<562:AASBT->2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIC LYMPHOCYTES; STRIATIONAL AUTOANTIBODIES; ANTIBODY-SYNTHESIS; INVITRO SYNTHESIS; THYMOMAS; PROTEIN; MODEL; CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Yoskikawa e V.A. Lennon, "ACETYLCHOLINE-RECEPTOR AUTOANTIBODY SECRETION BY THYMOCYTES - RELATIONSHIP TO MYASTHENIA-GRAVIS", Neurology, 49(2), 1997, pp. 562-567

Abstract

We tested thymus cells from 119 patients with acquired myasthenia gravis (MG) for in vitro production of acetylcholine receptor (AChR) binding antibodies (Ab); 109 were seropositive, of which 82 (75%) secretedAChRAb in vitro. As noted in earlier studies, thymus cell secretion of AChRAb paralleled serum Ab levels (rho(s) = 0.503; p < 0.0001; n = 119). Striational Ab secretion also correlated with the patients' serologic status. AChRAb secretion in vitro predicted the secretory activity of thymus cells implanted in severe combined immune deficiency (SCID) mice. Thymocytes from patients treated with corticosteroids made significantly less AChRAb than thymocytes from untreated patients (p < 0.005). Of particular note: (1) AChRAb was secreted by thymocytes from two of five nonimmunosuppressed patients who had generalized MG but whowere seronegative for AChR binding autoantibodies; and (2) AChRAb secretion fi om both thymic and nonthymic sources was documented in a patient with noninvasive thymoma whose first signs of MG appeared,eared 7months after thymectomy. We conclude that the thymus in a majority ofpatients with acquired MG is the principal but not the sole reservoirof immunocytes that specifically react with muscle antigens.

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Documento generato il 30/11/20 alle ore 19:42:23