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Titolo:
SINGLE-DOSE GADOLINIUM WITH MAGNETIZATION-TRANSFER VERSUS TRIPLE-DOSEGADOLINIUM IN THE MR DETECTION OF MULTIPLE-SCLEROSIS LESIONS
Autore:
VANWAESBERGHE JHTM; CASTELIJNS JA; ROSER W; SILVER N; YOUSRY T; NIJEHOLT GJLA; ADER HJ; UITDEHAAG BMJ; RADUE EW; POLMAN CH; KAPPOS L; MILLER DH; BARKHOF F;
Indirizzi:
FREE UNIV AMSTERDAM,ACAD HOSP,MR CTR MS RES,DEPT DIAGNOST RADIOL,DE BOELELAAN 1117 NL-1081 HV AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM,ACAD HOSP,MR CTR MS RES,DEPT NEUROL NL-1081 HV AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM,ACAD HOSP,MR CTR MS RES,DEPT EPIDEMIOL & BIOSTAT NL-1081 HV AMSTERDAM NETHERLANDS UNIV BASEL HOSP,KANTONSSPITAL,DEPT NEUROL & NEURORADIOL BASEL SWITZERLAND QUEEN SQ HOSP,INST NEUROL LONDON ENGLAND UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEURORADIOL D-8000 MUNICH GERMANY
Titolo Testata:
American journal of neuroradiology
fascicolo: 7, volume: 18, anno: 1997,
pagine: 1279 - 1285
SICI:
0195-6108(1997)18:7<1279:SGWMVT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESONANCE-IMAGING LESIONS; BRAIN-BARRIER BREAKDOWN; DISEASE-ACTIVITY; ENHANCING LESIONS; DTPA; ENHANCEMENT; DURATION; TRIALS;
Keywords:
MAGNETIC RESONANCE, COMPARATIVE STUDIES; MAGNETIC RESONANCE, MAGNETIZATION TRANSFER; SCLEROSIS, MULTIPLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.H.T.M. Vanwaesberghe et al., "SINGLE-DOSE GADOLINIUM WITH MAGNETIZATION-TRANSFER VERSUS TRIPLE-DOSEGADOLINIUM IN THE MR DETECTION OF MULTIPLE-SCLEROSIS LESIONS", American journal of neuroradiology, 18(7), 1997, pp. 1279-1285

Abstract

PURPOSE: To compare the efficacy of single-dose gadolinium with magnetization transfer contrast (MTC) with that of triple-dose gadolinium in detecting enhancing multiple sclerosis lesions. METHODS: Twenty-one patients with multiple sclerosis were examined with MR imaging first with 0.1 mmol/kg gadolinium (single dose) and then, after 24 to 72 hours, with 0.3 mmol/kg gadolinium (triple dose). T2-weighted fast spin-echo and T1-weighted spin-echo MR images with and without MTC were obtained before contrast administration followed by either T1-weighted spin-echo images with MTC (single dose) or conventional T1-weighted spin-echo images (triple dose), starting 5, 17, and 29 minutes after contrast administration. All images were evaluated in a blinded fashion and scored in random order by two readers. Outcome parameters included number of enhancing lesions, number of active MR examinations (those containing at least one enhancing lesion), contrast ratio (signal intensityof enhancing lesion divided by signal intensity of normal-appearing white matter), and size of enhancing lesions. RESULTS: Eighty-one percent more enhancing lesions and 49% more active MR examinations were detected when a triple dose of gadolinium was used as compared with a single dose. The level of agreement between readers as to the number of enhancing lesions was significantly higher for triple-dose than for single-dose gadolinium. With triple-dose gadolinium, contrast ratios and areas of enhancement increased by 10% and 33%, respectively. Delayed imaging increased the size of the lesion by 11% on single-dose MTC images and by 18% on triple-dose images. CONCLUSION: Triple-dose gadolinium is more effective (higher sensitivity and interobserver agreement) than single-dose gadolinium in combination with MTC in detecting enhancing multiple sclerosis lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:37:31