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Titolo:
NEUROMETABOLISM OF ACTIVE NEUROPSYCHIATRIC LUPUS DETERMINED WITH PROTON MR SPECTROSCOPY
Autore:
SIBBITT WL; HASELER LJ; GRIFFEY RR; FRIEDMAN SD; BROOKS WM;
Indirizzi:
UNIV NEW MEXICO,SCH MED,DEPT INTERNAL MED,DIV RHEUMATOL ALBUQUERQUE NM 87131 UNIV NEW MEXICO,SCH MED,CTR NONINVAS DIAG ALBUQUERQUE NM 87131
Titolo Testata:
American journal of neuroradiology
fascicolo: 7, volume: 18, anno: 1997,
pagine: 1271 - 1277
SICI:
0195-6108(1997)18:7<1271:NOANLD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; NERVOUS-SYSTEM INVOLVEMENT; LOCALIZED H-1-NMR SPECTRA; DISEASE-ACTIVITY INDEX; HUMAN-BRAIN; N-ACETYLASPARTATE; CEREBRAL METABOLITES; ALZHEIMER-DISEASE; ERYTHEMATOSUS; LESIONS;
Keywords:
LUPUS ERYTHEMATOSUS; MAGNETIC RESONANCE, SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
W.L. Sibbitt et al., "NEUROMETABOLISM OF ACTIVE NEUROPSYCHIATRIC LUPUS DETERMINED WITH PROTON MR SPECTROSCOPY", American journal of neuroradiology, 18(7), 1997, pp. 1271-1277

Abstract

PURPOSE: To determine the neurometabolism of patients with active neuropsychiatric systemic lupus erythematosus (NPSLE) by using proton MR spectroscopy. METHODS: Thirty-six patients with SLE and eight control subjects were studied with proton MR spectroscopy to measure brain metabolites. Peaks from N-acetylaspartate (NAA), creatine (Cr), choline (Cho), and at 1.3 parts per million (ppm) lipid, macromolecules, and lactate were measured. Patients were classified as having major NPSLE (seizures, psychosis, major cognitive dysfunction, delirium, stroke, or coma) (n = 15) or minor NPSLE (headache, minor affective disorder, or minor cognitive disorder) (n = 21). Patients with major NPSLE were severely ill and hospitalized. RESULTS: SLE patients had lower NAA and increased metabolites at 1.3 ppm than did control subjects (NAA/Cr-SLE =1.90 +/- 0.35, NAA/Cr-Control = 2.16 +/- 0.26; 1.3 ppm/Cr-SLE = 0.49 /- 0.41, 1.3 ppm/Cr-Control = 0.27 +/- 0.05). NAA/Cr in patients withcurrent or prior major NPSLE was lower than in patients without majorNPSLE. Increased peaks at 1.3 ppm were present in all SLE subgroups, but particularly in patients with major NPSLE. These resonances were not evident at an echo time of 136, indicating that these signals were not lactate. CONCLUSION: Major NPSLE, past or present, is associated with decreased levels of NAA. Elevated peaks around 1.3 ppm do not represent lactate even in severely ill patients, indicating that global ischemia is not characteristic of NPSLE. Neurochemical markers determined by MR spectroscopy may be useful for determining activity and degreeof brain injury in NPSLE.

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Documento generato il 02/04/20 alle ore 19:12:49