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Titolo:
EVIDENCE FOR THE INVOLVEMENT OF DOPAMINE-RECEPTORS IN ETHANOL-INDUCEDHYPERACTIVITY IN MICE
Autore:
COHEN C; PERRAULT G; SANGER DJ;
Indirizzi:
SYNTHELABO RECH,CNS RES DEPT,31 AVE PAUL VAILLANT COUTURIER F-92220 BAGNEUX FRANCE
Titolo Testata:
Neuropharmacology
fascicolo: 8, volume: 36, anno: 1997,
pagine: 1099 - 1108
SICI:
0028-3908(1997)36:8<1099:EFTIOD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR STIMULATION; SUBSTITUTED BENZAMIDE DRUGS; RECOMBINANT INBRED MICE; INDUCED EXCITATION; NUCLEUS-ACCUMBENS; IN-VIVO; RATS; AGONISTS; ANTAGONISTS; TIAPRIDE;
Keywords:
ETHANOL; LOCOMOTOR ACTIVITY; DOPAMINE ANTAGONISTS; DOPAMINE AGONISTS; LOSS OF RIGHTING REFLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
C. Cohen et al., "EVIDENCE FOR THE INVOLVEMENT OF DOPAMINE-RECEPTORS IN ETHANOL-INDUCEDHYPERACTIVITY IN MICE", Neuropharmacology, 36(8), 1997, pp. 1099-1108

Abstract

Based on the hypothesis that drugs of abuse increase locomotor activity through mechanisms related to reinforcement, i.e. the mesolimbic dopamine (DA) system, ethanol-induced hyperactivity might provide a screening model to investigate the effect of ethanol on reward pathways. In the present study, ethanol had bidirectional effects on locomotion in mice: hyperactivity at low doses (2-3 g/kg) and sedation at high doses (4-5 g/kg). Such high doses induced a loss of righting reflex (LRR). The stimulant effect of ethanol was blocked by the D-2/D-3 antagonists, haloperidol (0.2 mg/kg) and tiapride (30-60 mg/kg), and by the D-1antagonist, SCH 23390 (0.03 mg/kg) whereas the non selective DA antagonist, clozapine decreased ethanol-induced hyperactivity at a dose (1 mg/kg) which also decreased activity in control animals. Unlike haloperidol and clozapine which potentiated LRR induced by ethanol, the selective DA antagonists, tiapride and SCH 23390, had no effect. Pretreatment with the D-2/D-3 agonist, quinpirole (0.1-0.3 mg/kg), reduced hyperactivity induced by ethanol presumably by stimulation of pre-synapticreceptors but did not change LRR. The D-1 full agonist, SKF 81297 which produced hyperactivity by itself and the D-1 partial agonist, SKF 38393, did not specifically affect ethanol-induced activities. The results indicate that activation of D-1 and D-2/D-3 DA receptors is implicated in ethanol-induced hyperactivity whereas other mechanisms might mediate the sedative effects of ethanol. Tiapride and haloperidol, bothused in the management of alcohol dependence, might exert beneficial effects by counteracting the reinforcing effects of ethanol. Tiapride's lack of interaction with the depressant effects of ethanol may account for its better tolerance in alcoholic patients. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:09:25