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Titolo:
GENETIC RELATEDNESS OF BURKHOLDERIA (PSEUDOMONAS) CEPACIA ISOLATES FROM 5 CYSTIC-FIBROSIS CENTERS IN MICHIGAN
Autore:
KUMAR A; DIETRICH S; SCHNEIDER W; JACOBSON R; DOWNES FP; ROBINSONDUNN BE; HONICKY R; SMITH J; MARTIN R;
Indirizzi:
MICHIGAN STATE UNIV,C-201 E FEE HALL E LANSING MI 48824 MICHIGAN DEPT COMMUNITY HLTH LANSING MI 48909
Titolo Testata:
Respiratory medicine
fascicolo: 8, volume: 91, anno: 1997,
pagine: 485 - 492
SICI:
0954-6111(1997)91:8<485:GROB(C>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIELD GEL-ELECTROPHORESIS; TO-PERSON TRANSMISSION; FATTY-ACIDS; INFECTION; EPIDEMIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A. Kumar et al., "GENETIC RELATEDNESS OF BURKHOLDERIA (PSEUDOMONAS) CEPACIA ISOLATES FROM 5 CYSTIC-FIBROSIS CENTERS IN MICHIGAN", Respiratory medicine, 91(8), 1997, pp. 485-492

Abstract

Burkholderia cepacia isolates from patients with cystic fibrosis (CF)attending five CF centers were studied for relatedness by cellular fatty acid methyl esters (FAME) and by chromosomal DNA restriction analysis. Twenty-eight of 32 (87.5%) isolates tested were grouped in cluster group 1 based on their FAME profiles. DNA analysis revealed that 29 of 32 (90.6%) B. cepacia isolates from five CF centers had one closelyrelated DNA pattern. To examine strain variation over a time period, FAME profiles and DNA patterns of isolates from serial cultures on seven patients from center D were studied. For four patients, all serial B. cepacia isolates belonged to a single FAME cluster group; for the remaining three patients, all serial isolates belonged to any two of the four cluster groups. On serial culture isolates, a single DNA pattern (pattern A) was found in 31 of 32 isolates demonstrating a close genetic relatedness. These data corroborate the observations that the majority of patients colonised with B. cepacia in a CF center harbor strains genetically closely related as determined by FAME profiles and DNApatterns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:04:12