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Titolo:
EXPOSURE TO CHRONIC PSYCHOSOCIAL STRESS AND CORTICOSTERONE IN THE RAT- EFFECTS ON SPATIAL DISCRIMINATION-LEARNING AND HIPPOCAMPAL PROTEIN-KINASE C-GAMMA IMMUNOREACTIVITY
Autore:
KRUGERS HJ; DOUMA BRK; ANDRINGA G; BOHUS B; KORF J; LUITEN PGM;
Indirizzi:
UNIV AMSTERDAM,INST NEUROBIOL,KRUISLAAN 320 NL-1098 SM AMSTERDAM NETHERLANDS UNIV GRONINGEN,GRAD SCH BEHAV & COGNIT NEUROSCI,DEPT BIOL PSYCHIAT GRONINGEN NETHERLANDS UNIV GRONINGEN,GRAD SCH BEHAV & COGNIT NEUROSCI,DEPT ANIM PHYSIOL GRONINGEN NETHERLANDS
Titolo Testata:
Hippocampus
fascicolo: 4, volume: 7, anno: 1997,
pagine: 427 - 436
SICI:
1050-9631(1997)7:4<427:ETCPSA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PRIMED BURST POTENTIATION; DAY-OLD CHICKS; PKC-GAMMA; MONOCLONAL-ANTIBODIES; RECEPTOR ACTIVATION; MEMORY PERFORMANCE; PYRAMIDAL NEURONS; APICAL DENDRITES; AGED RATS;
Keywords:
LEARNING AND MEMORY; SPATIAL ORIENTATION; STRESS; CORTICOSTERONE; HIPPOCAMPUS; PROTEIN KINASE C; DENTATE GYRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Krugers et al., "EXPOSURE TO CHRONIC PSYCHOSOCIAL STRESS AND CORTICOSTERONE IN THE RAT- EFFECTS ON SPATIAL DISCRIMINATION-LEARNING AND HIPPOCAMPAL PROTEIN-KINASE C-GAMMA IMMUNOREACTIVITY", Hippocampus, 7(4), 1997, pp. 427-436

Abstract

Previous reports have demonstrated a striking increase of the immunoreactivity of the gamma-isoform of protein kinase C (PKC gamma-ir) in Ammon's horn and dentate gyrus (DC) of rodent hippocampus after training in a spatial orientation task. In the present study, we investigatedhow 8 days of psychosocial stress affects spatial discrimination learning in a hole board and influences PKC gamma-ir in the hippocampal formation. The acquisition of both reference memory and working memory was significantly delayed in the stressed animals during the entire training period. With respect to cellular plasticity, the training experience in both nonstressed and stressed groups yielded enhanced PKC gamma-ir in the CA1 and CA3 regions of the posterior hippocampus but not in subfields of the anterior hippocampus. Stress enhanced PKC gamma-ir in the DG and CA3 pyramidal cells of the anterior hippocampus. In stressed animals that were subsequently trained, the PKC gamma-ir was increased in the posterior CA1 region to the same level as that found in nonstressed trained animals. Stress apparently abrogated the PKC gamma-ir training response in the CA3 region. In a second experiment, the elevation of plasma corticosterone levels to values that are found during stress did not significantly influence reference memory scores but slightly and temporarily affected working memory. The training-induced enhancement of PKC gamma-ir in the CA1 region was similar in trained and corticosterone-treated trained animals, but the learning-induced PKC gamma-ir response in the posterior CA3 area was absent after corticosterone pretreatment. These results reveal that prolonged psychosocialstress causes spatial learning deficits, whereas artificial elevationof corticosterone levels to the levels that occur during stress only mildly affects spatial memory performance. The spatial learning deficits following stress are reflected only in part in the redistribution of hippocampal PKC gamma-ir following training. (C) 1997 Wiley-Liss, Inc.

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Documento generato il 08/04/20 alle ore 12:09:25