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Titolo:
CYP2D6 POLYMORPHISM IS NOT ASSOCIATED WITH ESSENTIAL TREMOR
Autore:
AGUNDEZ JAG; JIMENEZJIMENEZ FJ; TEJEDA R; LEDESMA MC; ORTIPAREJA M; GASALLA T; MOLINA JA; RUIZ J; CORIA F; DUARTE J; VAZQUEZ A; LADERO JM; BENITEZ J;
Indirizzi:
UNIV EXTREMADURA,FAC MED,DEPT FARMACOL,AVDA ELVAS S-N E-06071 BADAJOZSPAIN UNIV EXTREMADURA,SCH MED,DEPT PHARMACOL & PSYCHIAT BADAJOZ SPAIN HOSP UNIV PRINCIPE ASTURIAS,NEUROL SERV ALCALA DE HENARES SPAIN SAN CARLOS UNIV HOSP,GASTROENTEROL SERV MADRID SPAIN HOSP UNIV DOCE OCTUBRE,NEUROL SERV MADRID SPAIN HOSP GEN SEGOVIA,NEUROL SERV MADRID SPAIN HOSP UNIV SAN CARLOS,NEUROL SERV MADRID SPAIN
Titolo Testata:
European neurology
fascicolo: 2, volume: 38, anno: 1997,
pagine: 99 - 104
SICI:
0014-3022(1997)38:2<99:CPINAW>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE SYSTEM ATROPHY; HYDROXYLASE GENE POLYMORPHISM; PARKINSONS-DISEASE; OXIDATIVE POLYMORPHISM; ALZHEIMERS-DISEASE; DRUG-METABOLISM; MUTANT ALLELES; DEBRISOQUINE; SUSCEPTIBILITY; AMPLIFICATION;
Keywords:
ESSENTIAL TREMOR; DEBRISOQUINE; POLYMORPHISM; ETIOLOGY; GENETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
J.A.G. Agundez et al., "CYP2D6 POLYMORPHISM IS NOT ASSOCIATED WITH ESSENTIAL TREMOR", European neurology, 38(2), 1997, pp. 99-104

Abstract

Recent reports have shown an association between cytochrome P450IID6 (CYP2D6) polymorphism and Parkinson's disease. We investigated the association between this polymorphism and the risk for developing essential tremor (ET). Leukocytic DNA from 91 unrelated ET patients and a control group of 258 unrelated healthy individuals was studied for the occurrence of eight different CYP2D6 allelic variants by using allele-specific PCR amplification XbaI and EcoRI-RFLP's analyses. The prevalence for these allelic variants in the ET and control groups were, respectively: CYP2D61 76.9 and 78.7%, CYP2D6*2 0.5 and 0.2%, CYP2D6*3 0 and1%, CYP2D64 12.1 and 12.2%, CYP2D6*5 1.6 and 1.7%, CYP2D6*9 4.4 and 2.9%, CYP2D62x2 4.4 and 3.2%. The prevalence of subjects with absent CYP2D6 activity (those carrying two defect genes) was 1.1 and 3.1% in ET and control groups, respectively. Both groups studied were in Hardy-Weinberg equilibrium. These results indicate that mutations at the CYP2D6 gene do not seem to be a major factor in determining susceptibility to ET, and reinforces the view that ET and parkinsonism are distinct conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:22:28