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Titolo:
SCHEDULE INDUCTION CONDITIONS NOT ONLY EXAGGERATE INTAKE BUT ALSO ENHANCE DRUG SOLUTION CHOICE
Autore:
FALK JL; NEAL SA; LAU CE;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL,BUSCH CAMPUS NEW BRUNSWICK NJ 08903
Titolo Testata:
Physiology & behavior
fascicolo: 3, volume: 62, anno: 1997,
pagine: 479 - 483
SICI:
0031-9384(1997)62:3<479:SICNOE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE;
Keywords:
DRUG PREFERENCE; LIDOCAINE; SCHEDULE-INDUCED POLYDIPSIA; DRUG SELF-ADMINISTRATION; ORAL DRUG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Falk et al., "SCHEDULE INDUCTION CONDITIONS NOT ONLY EXAGGERATE INTAKE BUT ALSO ENHANCE DRUG SOLUTION CHOICE", Physiology & behavior, 62(3), 1997, pp. 479-483

Abstract

In previous research, rats exposed to daily, 3 h sessions of scheduleinduced polydipsia (SIP) self-administered high doses of cocaine orally. However, a strong and durable preference for cocaine solution to water requires training in addition to mere oral self-administration exposure. If cocaine is dissolved in a preferred vehicle solution, and the vehicle is subsequently faded to water, then a strong preference for cocaine remains. A similar preference can be instituted for lidocaine solution. Such preferences may develop because the gustatory property of a drug becomes associated with the preferred vehicle and remains to function as a durable conditioned reinforcer after vehicle fading. To determine if drug preference is solely a function of this posited conditioning mechanism, or whether it also depends upon the STP condition, rats were exposed to daily, 3 h sessions of single-ration feeding,rather than the SIP condition. A preferred vehicle (glucose/saccharinsolution) was slowly faded from a 0.19 mg/ml lidocaine solution, which was presented concurrently with a choice for water. Although a preference for lidocaine solution to water could be generated, it occurred for only 5 out of 9 rats, and the preference was relatively unstable. By contrast, in two previous studies using SIP, 26 out of 27 rats maintained a preference for lidocaine solution. Thus, SIP nor only exaggerates the amount of drug solution ingested but also contributes to the fixation of the associative drug solution choice. (C) 1997 Elsevier Science Inc.

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Documento generato il 09/04/20 alle ore 00:27:21