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Titolo:
PULMONARY-FUNCTION IN OBESE SNORERS WITH OR WITHOUT SLEEP-APNEA SYNDROME
Autore:
ZERAHLANCNER F; LOFASO F; COSTE A; RICOLFI F; GOLDENBERG F; HARF A;
Indirizzi:
HOP HENRI MONDOR,SERV PHYSIOL EXPLORAT FONCTIONNELLES F-94010 CRETEILFRANCE HOP HENRI MONDOR,SERV OTORHINOLARYNGOL & NEURORADIOL F-94010 CRETEIL FRANCE HOP HENRI MONDOR,INSERM,U296 F-94010 CRETEIL FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 2, volume: 156, anno: 1997,
pagine: 522 - 527
SICI:
1073-449X(1997)156:2<522:PIOSWO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLOW-VOLUME CURVES; RESPIRATORY RESISTANCE; AIRWAY-OBSTRUCTION; FORCED OSCILLATION; HYPERTENSION; HYPERCAPNIA; DEPENDENCE; FREQUENCY; COMMUNITY; POSTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
F. Zerahlancner et al., "PULMONARY-FUNCTION IN OBESE SNORERS WITH OR WITHOUT SLEEP-APNEA SYNDROME", American journal of respiratory and critical care medicine, 156(2), 1997, pp. 522-527

Abstract

We evaluated pulmonary function abnormalities associated with the sleep apnea syndrome (SAS) in 170 habitual snorers without SAS (n = 62, apnea-hypopnea index [AHI] < 10 per hour of sleep), with moderately severe SAS (n = 56, 10 less than or equal to Al-ii < 30) or with severe SAS (n = 52, AHI greater than or equal to 30). The three groups were similar regarding obesity (BMI similar to 30 kg.m(-2)) and smoking history (similar to 20 pack-years). Pulmonary function was assessed by spirometry, forced oscillation mechanics, and gas exchange studies. Forcedexpiratory flows decreased as the SAS severity increased (p < 0.001, p < 0.02, and p < 0.05 for FEF50, FEV1, and FEV1/VC, respectively). Multiple regression analysis showed that the correlation between FEV50 and the AHI persisted when smoking history was taken into account (p < 0.05), suggesting that SAS may be an independent risk factor for smallairway disease. A highly significant correlation was found between specific respiratory conductance (sGrs) and the AHI (p < 0.0001). In a multiple regression analysis (p < 0.0001), variables that influenced sGrs were distal airway obstruction as assessed by FEV50 (p < 0.05), morphological upper airway abnormalities as assessed by cephalometric parameters (p < 0.02), and the AHI (p < 0.0005). SAS appears to be highlycorrelated to lower and upper airway obstruction, as demonstrated by a reduction in specific respiratory conductance, which adds to the increase in breathing load due to obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:48:24