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Titolo:
ESSENTIAL ROLE OF POU-DOMAIN FACTOR BRN-3C IN AUDITORY AND VESTIBULARHAIR CELL-DEVELOPMENT
Autore:
XIANG MQ; GAN L; LI DQ; CHEN ZY; ZHOU LJ; OMALLEY BW; KLEIN W; NATHANS J;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT GENET & MOL BIOL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT GENET & MOL BIOL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT OTOLARYNGOL HEAD & NECK SURG BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI & OPHTHALMOL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST BALTIMORE MD 21205 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT PEDIAT,CTR ADV BIOTECHNOL & MED PISCATAWAY NJ 08854 UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT BIOCHEM & MOL BIOL HOUSTON TX 77030
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 17, volume: 94, anno: 1997,
pagine: 9445 - 9450
SICI:
0027-8424(1997)94:17<9445:EROPFB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING INNER-EAR; TRANSCRIPTION FACTOR; NEUROTROPHIC FACTOR; MESSENGER-RNAS; C-ELEGANS; EXPRESSION; NEURONS; MUTATIONS; PROTEIN; MOUSE;
Keywords:
INNER EAR DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.Q. Xiang et al., "ESSENTIAL ROLE OF POU-DOMAIN FACTOR BRN-3C IN AUDITORY AND VESTIBULARHAIR CELL-DEVELOPMENT", Proceedings of the National Academy of Sciences of the United Statesof America, 94(17), 1997, pp. 9445-9450

Abstract

The Brn-3 subfamily of POU-domain transcription factor genes consistsof three highly homologous members-Brn-3a, Brn-3b, and Brn-3c-that are expressed in sensory neurons and in a small number of brainstem nuclei, This paper describes the role of Brn-3c in auditory and vestibularsystem development, In the inner ear, the Brn-3c protein is found only in auditory and vestibular hair cells, and the Brn-3a and Brn-3b proteins are found only in subsets of spiral and vestibular ganglion neurons, Mice carrying a targeted deletion of the Brn-3c gene are deaf andhave impaired balance, These defects reflect a complete loss of auditory and vestibular hair cells during the late embryonic and early postnatal period and a secondary loss of spiral and vestibular ganglion neurons. Together with earlier work demonstrating a loss of trigeminal ganglion neurons and retinal ganglion cells in mice carrying targeted disruptions in the Brn-3a and Brn-3b genes, respectively, the Brn-Sc phenotype reported here demonstrates that each of the Brn-3 genes plays distinctive roles in the somatosensory, visual, and auditory/vestibular systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:16:02