Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VASCULAR MADS - 2 NOVEL MAD-RELATED GENES SELECTIVELY INDUCIBLE BY FLOW IN HUMAN VASCULAR ENDOTHELIUM
Autore:
TOPPER JN; CAI JX; QIU YB; ANDERSON KR; XU YY; DEEDS JD; FEELEY R; GIMENO CJ; WOOLF EA; TAYBER O; MAYS GG; SAMPSON BA; SCHOEN FJ; GIMBRONE MA; FALB D;
Indirizzi:
BRIGHAM & WOMENS HOSP,DIV VASC RES,221 LONGWOOD AVE,LMRC 401 BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DIV VASC RES BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT MED BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DIV CARDIOVASC,DEPT MED BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115 MILLENNIUM PHARMACEUT CAMBRIDGE MA 02139
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 17, volume: 94, anno: 1997,
pagine: 9314 - 9319
SICI:
0027-8424(1997)94:17<9314:VM-2NM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J.N. Topper et al., "VASCULAR MADS - 2 NOVEL MAD-RELATED GENES SELECTIVELY INDUCIBLE BY FLOW IN HUMAN VASCULAR ENDOTHELIUM", Proceedings of the National Academy of Sciences of the United Statesof America, 94(17), 1997, pp. 9314-9319

Abstract

Vascular endothelium is an important transducer and integrator of both humoral and biomechanical stimuli within the cardiovascular system, Utilizing a differential display approach, we have identified two genes, Smad6 and Smad7, encoding members of the MAD-related family of molecules, selectively induced in cultured human vascular endothelial cells by steady laminar shear stress, a physiologic fluid mechanical stimulus. MAD-related proteins are a recently identified family of intracellular proteins that are thought to be essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. Smad6 and Smad7 possess unique structural features (compared with previously described MADs), and theycan physically interact with each other, and, in the Ease of Smad6, with other known human MAD species, in endothelial cells, Transient expression of Smad6 or Smad7 in vascular endothelial cells inhibits the activation of a transfected reporter gene in response to both TGF-P andfluid mechanical stimulation, Both Smad6 and Smad7 exhibit a selective pattern of expression in human vascular endothelium in vivo as detected by immunohistochemistry and in situ hybridization. Thus, Smad6 andSmad7 constitute a novel class of MAD-related proteins, termed vascular MADs, that are induced by fluid mechanical forces and tan modulate gene expression In response to both humoral and biomechanical stimulation in vascular endothelium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:29:14