Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STIMULATION OF IMMEDIATE-EARLY GENE-EXPRESSION BY DESIPRAMINE IN RAT-BRAIN
Autore:
DAHMEN N; FEHR C; REUSS S; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55131 MAINZ GERMANY UNIV MAINZ,DEPT ANAT D-55131 MAINZ GERMANY
Titolo Testata:
Biological psychiatry
fascicolo: 5, volume: 42, anno: 1997,
pagine: 317 - 323
SICI:
0006-3223(1997)42:5<317:SOIGBD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; NERVE GROWTH-FACTOR; JUN PROTO-ONCOGENE; C-FOS; TRANSCRIPTION; INDUCTION; DNA; ZIF268/EGR-1; ACTIVATION; UPSTREAM;
Keywords:
DESIPRAMINE; TRICYCLIC ANTIDEPRESSANTS; C-FOS; C-JUN; ZIF268; GENE REGULATION; RAT BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
N. Dahmen et al., "STIMULATION OF IMMEDIATE-EARLY GENE-EXPRESSION BY DESIPRAMINE IN RAT-BRAIN", Biological psychiatry, 42(5), 1997, pp. 317-323

Abstract

The stimulation of immediate early gene expression in brain nad neuronal cell culture systems has been reported after various experimental paradigms such as chemiconvulsant-provoked seizures or specific drug applications. In particular, the induction of immediate early genes by adrenergic model substances has been demonstrated by several investigators. This report demonstrates that a single dose of desipramine (10 or 25 mg/kg), a classical tricyclic antidepressant drug acting on the adrenergic system, induced c-fos and zif268 expression in rat hippocampus without affecting c-jun. The observed immediate early gene responsemight reflect part of a signal transduction cascade involved in long-term neuroadaptive and behavioral changes after antidepressant drug treatment. (C) 1997 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:48:40