Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE NEUROBIOLOGY OF DRUG-ADDICTION
Autore:
KOOB GF; NESTLER EJ;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT NEUROPHARMACOL,CVN-7,10550 N TORREY PINES RD LA JOLLA CA 92037 CONNECTICUT MENTAL HLTH CTR NEW HAVEN CT 00000 YALE UNIV,SCH MED,LAB MOL PSYCHIAT NEW HAVEN CT 00000
Titolo Testata:
The Journal of neuropsychiatry and clinical neurosciences
fascicolo: 3, volume: 9, anno: 1997,
pagine: 482 - 497
SICI:
0895-0172(1997)9:3<482:TNOD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS NEURONS; NICOTINE ABSTINENCE SYNDROME; MESOLIMBIC DOPAMINE SYSTEM; INDUCED LOCOMOTOR-ACTIVITY; RAT NUCLEUS-ACCUMBENS; OPIATE-WITHDRAWAL; BRAIN-STIMULATION; SELF-STIMULATION; ETHANOL WITHDRAWAL; 6-HYDROXYDOPAMINE LESIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
168
Recensione:
Indirizzi per estratti:
Citazione:
G.F. Koob e E.J. Nestler, "THE NEUROBIOLOGY OF DRUG-ADDICTION", The Journal of neuropsychiatry and clinical neurosciences, 9(3), 1997, pp. 482-497

Abstract

Animal models have begun to provide insights into the neurobiologicalbasis of reinforcement in drug addiction. The reinforcing effects of indirect sympathomimetics such as cocaine and amphetamine appear to depend on release of dopamine in the terminal fields of the mesocorticolimbic dopamine system. The acute reinforcing effects of opiates involve not only an activation of dopamine, but also dopamine-independent elements in the terminal regions of the mesocorticolimbic dopamine system. Nicotine's reinforcing effects may involve both dopaminergic and opioid peptidergic systems. Ethanol's reinforcing effects may result from multiple neurotransmitter interactions including gamma-aminobutyric acid, glutamate, dopamine, opioid peptides, and serotonin. Subtle changes in neurochemical function and signal transduction and transcription mechanisms in sensitive neuronal elements in the extended amygdala may be mediators of chronic drug action that lead to vulnerability to relapse and may provide exciting insight into the neuroadaptations associated with drug addiction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:52:08