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Titolo:
PREOPERATIVE ASSESSMENT OF AXILLARY LYMPH-NODE STATUS IN PATIENTS WITH BREAST ADENOCARCINOMA USING INTRAVENOUS (99M)TECHNETIUM MAB-170H.82 (TRUSCINT(R)AD(TM))
Autore:
DESSUREAULT S; KOVEN I; REILLY RM; COUTURE J; SCHMOCKER B; DAMANI M; KIRSH J; ICHISE M; SIDLOFSKY S; MCEWAN AJB; BONIFACE G; STERN H; GALLINGER S;
Indirizzi:
MT SINAI HOSP,DEPT SURG,1225-600 UNIV AVE TORONTO ON M5G 1X5 CANADA UNIV TORONTO,TORONTO HOSP,DIV NUCL MED TORONTO ON M5G 1X5 CANADA MT SINAI HOSP,DEPT RADIOL TORONTO ON M5G 1X5 CANADA MT SINAI HOSP,DEPT SURG TORONTO ON M5G 1X5 CANADA BIOMIRA INC EDMONTON AB T6N 1H1 CANADA CROSS CANC INST EDMONTON AB T6N 1H1 CANADA
Titolo Testata:
Breast cancer research and treatment
fascicolo: 1, volume: 45, anno: 1997,
pagine: 29 - 37
SICI:
0167-6806(1997)45:1<29:PAOALS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEA MONOCLONAL-ANTIBODY; BW 431/26; CANCER; IMMUNOLYMPHOSCINTIGRAPHY; CARCINOMA; RADIOIMMUNOSCINTIGRAPHY; LYMPHOSCINTIGRAPHY; TECHNETIUM-99M; METASTASES; 170H.82;
Keywords:
AXILLARY IMAGING; BREAST ADENOCARCINOMA; IMMUNOSCINTIGRAPY; TC-99M-MAB-170H.82; TRUSCINT(R)AD(TM);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
S. Dessureault et al., "PREOPERATIVE ASSESSMENT OF AXILLARY LYMPH-NODE STATUS IN PATIENTS WITH BREAST ADENOCARCINOMA USING INTRAVENOUS (99M)TECHNETIUM MAB-170H.82 (TRUSCINT(R)AD(TM))", Breast cancer research and treatment, 45(1), 1997, pp. 29-37

Abstract

Immunoscintigraphy of the axilla has potential utility for the diagnostic and prognostic assessment of patients with breast adenocarcinoma.mAb-170H.82 is a murine monoclonal antibody (mAb) derived against synthetic Thomsen-Friedenreich (TF) antigen. Tru-Scint(R)AD(TM), a Tc-99m-mAb-170H.82 immunoconjugate, has previously been shown to localize invarious human adenocarcinomas. The purpose of this study was to evaluate the accuracy of this immunoconjugate in the pre-operative assessment of axillary lymph nodes in patients with known breast adenocarcinoma. Sixteen patients with documented primary breast cancer were injected intravenously with 1 mg of immunoconjugate (radioactivity 1.8 GBq) and imaged 22-24 hrs post-injection. Both planar and single photon emission computed tomographic (SPECT) images were obtained and reviewed ina blinded fashion. Imaging results were compared with surgical and pathological findings. Seven of 16 patients were found to have histologically positive axillary nodes: 5 of these sites were detected by immunoscintigraphy (sensitivity = 71%). Nine patients had pathologically disease-free axillary nodes: only 1 of these was misidentified as positive by immunoscintigraphy (specificity = 89%). These results suggest that immunoscintigraphy with Tc-99m-mAb-170H.82 has promise in the detection of axillary lymph node involvement in patients with breast cancer. Further studies are warranted to define the role of immunoscintigraphy in axillary staging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:43:29