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Titolo:
EFFECTS OF 5-HT3 RECEPTOR AGONISTS ON VOLUNTARY ETHANOL INTAKE IN RATS MAINTAINED ON A LIMITED ACCESS PROCEDURE
Autore:
DYR W; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND
Titolo Testata:
Alcohol and alcoholism
fascicolo: 4, volume: 32, anno: 1997,
pagine: 455 - 462
SICI:
0735-0414(1997)32:4<455:EO5RAO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONIST ICS 205-930; NUCLEUS-ACCUMBENS; ALCOHOL PREFERENCE; RECOGNITION SITES; MESOLIMBIC SYSTEM; DOPAMINE RELEASE; BRAIN; CONSUMPTION; ONDANSETRON; CHLOROPHENYLBIGUANIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
W. Dyr e W. Kostowski, "EFFECTS OF 5-HT3 RECEPTOR AGONISTS ON VOLUNTARY ETHANOL INTAKE IN RATS MAINTAINED ON A LIMITED ACCESS PROCEDURE", Alcohol and alcoholism, 32(4), 1997, pp. 455-462

Abstract

Recent evidence from a variety of laboratory studies suggests that the central effects of ethanol (EtOH) are mediated by serotonin 5-HT3 receptors. Notably, EtOH is able to potentiate 5-HT action on 5-HT3 ionophore, and 5-HT3 antagonists are known to reduce certain effects of EtOH. In the present study, we evaluated the effects of two agonists of 5-HT3 receptors, 2-methyl-5-HT (2-Me-5-HT) and m-chlorophenylbiguanide(m-CPBG) that were microinjected i.c.v. and into the nucleus accumbens (NAC) on EtOH intake in Wistar rats with high EtOH preference. 2-Me-5-HT given i.c.v. (1 and 10 mu g per rat) and into the NAC (bilaterally 1 and 10 mu g per site) significantly reduced EtOH intake in the limited access paradigm (2h session). On the other hand m-CPBG was inactive after intra-NAC administration It is concluded that central 5-HT3 receptors are involved in the regulation of EtOH consumption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:58:26