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Titolo:
BETA-GALACTOSIDASE-LABELED RELAY NEURONS OF HOMOTOPIC OLFACTORY-BULB TRANSPLANTS ESTABLISH PROPER AFFERENT AND EFFERENT SYNAPTIC CONNECTIONS WITH HOST NEURONS
Autore:
SEKERKOVA G; KATAROVA Z; MUGNAINI E; JOO F; WOLFF JR; PRODAN S; SZABO G;
Indirizzi:
HUNGARIAN ACAD SCI,BIOL RES CTR,INST BIOCHEM,TEMESVARI KRT 62 H-6701 SZEGED HUNGARY HUNGARIAN ACAD SCI,BIOL RES CTR,INST BIOCHEM H-6701 SZEGED HUNGARY HUNGARIAN ACAD SCI,BIOL RES CTR,INST BIOPHYS H-6701 SZEGED HUNGARY NORTHWESTERN UNIV,INST NEUROSCI CHICAGO IL 60611 UNIV GOTTINGEN,DEPT ANAT D-37075 GOTTINGEN GERMANY
Titolo Testata:
Neuroscience
fascicolo: 4, volume: 80, anno: 1997,
pagine: 973 - 979
SICI:
0306-4522(1997)80:4<973:BRNOHO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL RATS; FOREBRAIN; REGENERATION; BULBECTOMY; MATURATION; PLASTICITY; MIGRATION; CORTEX; AXONS;
Keywords:
HOMOTOPIC GRAFT; LACZ; MITRAL/TUFTED CELLS; NEURONAL REGENERATION; SYNAPTOGENESIS; TRANSGENIC MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G. Sekerkova et al., "BETA-GALACTOSIDASE-LABELED RELAY NEURONS OF HOMOTOPIC OLFACTORY-BULB TRANSPLANTS ESTABLISH PROPER AFFERENT AND EFFERENT SYNAPTIC CONNECTIONS WITH HOST NEURONS", Neuroscience, 80(4), 1997, pp. 973-979

Abstract

The vertebrate olfactory system has long been an attractive model forstudying neuronal regeneration and adaptive plasticity due to the continuous neurogenesis and synaptic remodelling throughout adult life inprimary and secondary olfactory centres,(10,11,15,16,18) its precisely ordered synaptic network(6,13,24) and accessibility for manipulation, After homotopic transplantation of fetal olfactory bulbs in bulbectomized neonatal rodents, newly regenerated olfactory neurons form glomeruli within the graft,(5,8,20,29,30) and the efferent mitral/tufted cells of the transplant innervate the host brain, terminating in higher olfactory centres.(14,28,30) However, the synaptic connections of the transplanted relay neurons within the graft and/or host's olfactory centres could not be characterized mainly because of lack of suitable cell-specific markers for these neurons, In this study, we have used olfactory bulbs from transgenic fetuses, in which the majority of the mitral/tufted cells express the bacterial enzyme beta-galactosidase, for homotopic olfactory bulb transplantation following complete unilateralbulbectomy. In the transplants, the cell bodies and terminals of the donor mitral/tufted cells were identified by beta-galactosidase histochemistry and immunocytochemistry at both light and electron microscopelevels, We demonstrate that transplanted relay neurons re-establish specific synaptic connections with host neurons of the periphery? source of the primary signal and central nervous system, thereby providing the basis for a functional recovery in the lesioned olfactory system. (C) 1997 LBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:21:27