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Titolo:
CONTRASTING EFFECTS OF EXCITOTOXIC LESIONS OF THE PREFRONTAL CORTEX ON THE BEHAVIORAL-RESPONSE TO D-AMPHETAMINE AND PRESYNAPTIC AND POSTSYNAPTIC MEASURES OF STRIATAL DOPAMINE FUNCTION IN MONKEYS
Autore:
WILKINSON LS; DIAS R; THOMAS KL; AUGOOD SJ; EVERITT BJ; ROBBINS TW; ROBERTS AC;
Indirizzi:
UNIV CAMBRIDGE,DEPT EXPT PSYCHOL,DOWNING ST CAMBRIDGE CB2 3EB ENGLAND UNIV CAMBRIDGE,DEPT EXPT PSYCHOL CAMBRIDGE CB2 3EB ENGLAND BABRAHAM INST,DEPT NEUROBIOL CAMBRIDGE CB2 4AT ENGLAND UNIV CAMBRIDGE,DEPT ANAT CAMBRIDGE CB2 3DY ENGLAND MRC,MOL BIOL LAB,DIV NEUROBIOL CAMBRIDGE CB2 2QD ENGLAND
Titolo Testata:
Neuroscience
fascicolo: 3, volume: 80, anno: 1997,
pagine: 717 - 730
SICI:
0306-4522(1997)80:3<717:CEOELO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; MPTP-TREATED MONKEYS; NUCLEUS-ACCUMBENS; 6-HYDROXYDOPAMINE LESIONS; CAUDATE-NUCLEUS; OBJECT RETRIEVAL; MESSENGER-RNAS; FRONTAL-CORTEX; RAT; RECEPTOR;
Keywords:
PREFRONTAL CORTEX; D-AMPHETAMINE; OBJECT RETRIEVAL; CAUDATE DOPAMINE RELEASE; STRIATAL DOPAMINE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Wilkinson et al., "CONTRASTING EFFECTS OF EXCITOTOXIC LESIONS OF THE PREFRONTAL CORTEX ON THE BEHAVIORAL-RESPONSE TO D-AMPHETAMINE AND PRESYNAPTIC AND POSTSYNAPTIC MEASURES OF STRIATAL DOPAMINE FUNCTION IN MONKEYS", Neuroscience, 80(3), 1997, pp. 717-730

Abstract

The effects of excitotoxic lesions of the prefrontal cortex on behavioural, neurochemical and molecular indices of dopamine function in thecaudate nucleus were studied in the marmoset. The lesion, which encompassed both the lateral and orbital regions of prefrontal cortex, madethe animals more sensitive to the performance disrupting effects of the dopamine releasing drug, D-amphetamine, in a variation of the object retrieval task. Specifically, following drug administration, the lesioned marmosets were less able to gain access to food reward in the minimum number of responses. Analysis of the nature of the errors suggested that the deficit was not due to inhibition of a prepotent responseas the lesioned monkeys were just as likely to make a detour reach tothe unopened side of the box as a direct ''line-of-sight'' reach intothe unopened front of the box. Rather, the data indicated a general disorganization of behaviour. The enhanced behavioural responsiveness to manipulations increasing presynaptic dopamine function was accompanied by neurochemical changes indicating a reduced responsiveness, as revealed by in vivo microdialysis. Thus, in lesioned animals, whilst there were no effects on baseline levels of extracellular dopamine in dorsolateral caudate, evoked release, both to systemic D-amphetamine and to a local depolarizing pulse of potassium ions, was attenuated. Theseopposite effects of the prefrontal cortex lesion on behavioural and neurochemical indices of striatal dopamine function occurred in the absence of any changes in striatal dopamine receptors of the D-1 and D-2 subtype, as determined both by radioligand binding assays and measurements of messenger RNA using in situ hydridization techniques. These data provide further insight into the interactions between prefrontal cortex and striatal dopamine function in the non-human primate. In particular, when taken in the light of our previous studies they indicate that following prefrontal manipulations, concurrence between behavioural and neurochemical indices of striatal dopamine function depends, critically, on the behavioural task. These findings are discussed with respect to the growing body of evidence implicating abnormalities in frontostriatal neurotransmission in complex disorders such as schizophrenia. (C) 1997 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:22:39