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Titolo:
RU24969 INDUCED BEHAVIORAL SYNDROME REQUIRES ACTIVATION OF BOTH 5HT(1A) AND 5HT(1B) RECEPTORS
Autore:
ONEILL MF; PARAMESWARAN T;
Indirizzi:
LILLY RES CTR LTD,ERL WOOD MANOR,SUNNINGHILL RD WINDLESHAM GU20 6PH SURREY ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 132, anno: 1997,
pagine: 255 - 260
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCOMOTOR-ACTIVITY; 5-HT1B RECEPTOR; MICE; RATS; LOCALIZATION; INHIBITION; RU-24969; RELEASE; AGONIST;
Keywords:
RU24969; 5HT(1A) RECEPTORS; 5HT(1B) RECEPTORS; ANPIRTOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Oneill e T. Parameswaran, "RU24969 INDUCED BEHAVIORAL SYNDROME REQUIRES ACTIVATION OF BOTH 5HT(1A) AND 5HT(1B) RECEPTORS", Psychopharmacology, 132(3), 1997, pp. 255-260

Abstract

The behavioural profiles of the mixed 5HT(1A/B) agonist RU24969 and the more selective 5HT(1B) agonist anpirtoline were compared. Both compounds induce an increase in activity as measured in photocell activitycages. The behaviours displayed by the rats receiving each treatment differed markedly, with RU24969 inducing flat body posture and circling of the cage perimeter (1.25-10 mg/kg SC), whereas anpirtoline increased ambulation characterised by a hopping motion (1.25-5.0 mg/kg SC). The effects of RU24969 were attenuated by both the 5HT(1A) antagonist WAY 100635 (0.03-1.25 mg/kg SC) and the 5HT(1B/D) antagonist GR127935 (1.0-5.0 mg/kg SC). Anpirtoline-induced behaviour was attenuated by GR127935 across the same dose range but was largely unaffected by WAY100635 even at doses above those which had blocked the effects of RU24969. Coadministration of the selective 5HT(1A) agonist 8-OH-DPAT (0.03-1.25 mg/kg SC) with anpirtoline (2.5 mg/kg) induced a dramatic increase in locomotor activity and a behavioural syndrome identical to that produced by RU24969. Thus it would appear that a synergistic effect of stimulation of both 5HT(1A) and 5HT(1B) receptors underlies the behavioural effects of RU24969, while anpirtoline acts mainly via stimulation of 5HT(1B) receptors only.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:36:26