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Titolo:
RAPID DRUG SUSCEPTIBILITY OF MYCOBACTERIUM-AVIUM COMPLEX USING A FLUORESCENCE QUENCHING METHOD
Autore:
MARONE P; BONO L; CARRETTO E; BARBARINI D; TELECCO S;
Indirizzi:
POLICLIN SAN MATTEO,IRCCS,LAB BATTERIOL & MICOL,AREA INFETTIVOL,INFECTIVOL SECT,VIA TARAMELLI 5 I-27100 PAVIA ITALY
Titolo Testata:
Journal of chemotherapy
fascicolo: 4, volume: 9, anno: 1997,
pagine: 247 - 250
SICI:
1120-009X(1997)9:4<247:RDSOMC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Keywords:
MYCOBACTERIUM AVIUM COMPLEX; ANTIMICROBIAL SUSCEPTIBILITY TEST; FLUORESCENCE QUENCHING METHOD; AGAR DILUTION METHOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
P. Marone et al., "RAPID DRUG SUSCEPTIBILITY OF MYCOBACTERIUM-AVIUM COMPLEX USING A FLUORESCENCE QUENCHING METHOD", Journal of chemotherapy, 9(4), 1997, pp. 247-250

Abstract

Mycobacteria Growth Indicator Tube (MGIT) is a recently introduced rapid growth detection method which uses an oxygen quenched fluorescent indicator. The present study evaluated the ability of this new method to determine the drug susceptibility of Mycobacterium avium complex (MAC). Thirty strains recovered from patients with AIDS were tested for susceptibility to clarithromycin, rifabutin, ciprofloxacin, azithromycin and amikacin using MGIT. Results were compared to susceptibilities determined by the agar dilution method. The results obtained showed a 100% correlation between MGIT and the agar dilution method for rifabutin and clarithromycin. There was a 100% correlation between the two methods for azithromycin against 27 strains. MGIT was well correlated with the agar dilution method for detecting resistance to clarithromycin, rifabutin and azithromycin in 4 days, but the correlation was poor when susceptibilities to ciprofloxacin and amikacin were determined. This rapid method is non-radiometric, noninvasive and does not require any special instruments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:38:26