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Titolo:
GANGLIOSIDE EXPRESSION IN LUNG-CANCER CELL-LINES
Autore:
FUENTES R; ALLMAN R; MASON MD;
Indirizzi:
VELINDRE HOSP,RES DEPT CARDIFF CF4 7XL S GLAM WALES VELINDRE HOSP,RES DEPT CARDIFF CF4 7XL S GLAM WALES
Titolo Testata:
Lung cancer
fascicolo: 1, volume: 18, anno: 1997,
pagine: 21 - 33
SICI:
0169-5002(1997)18:1<21:GEILC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-MELANOMA CELLS; HUMAN-MALIGNANT MELANOMA; CARBOHYDRATE ANTIGENS; CHOLERA-TOXIN; MONOCLONAL-ANTIBODIES; NORMAL-TISSUES; GD3; GROWTH; SURFACE; INVITRO;
Keywords:
LUNG CANCER; CELL LINES; GANGLIOSIDES; ALPHA-V INTEGRIN RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
R. Fuentes et al., "GANGLIOSIDE EXPRESSION IN LUNG-CANCER CELL-LINES", Lung cancer, 18(1), 1997, pp. 21-33

Abstract

Gangliosides are complex glycolipid constituents of cell membranes. They are involved in many biological functions including cell-cell recognition, cell-matrix attachment, cell growth and cell differentiation. Analysis of tumour associated gangliosides may aid in the characterisation of tumour cells and their degree of malignant transformation. Wehave characterised a total of eight lung cancer cell lines (four small cell and four non-small cell lung cancer) with respect to ganglioside and alpha v integrin receptor expression. Ganglioside GD3 was detected using the monoclonal antibody R24. Ganglioside GM1 was detected using the beta-subunit of cholera toxin. Ganglioside 9-O-acetyl GD3 and the alpha v integrin receptor were measured using commercially available monoclonal antibodies. Our results indicate that small cell lung cancer cell lines express significant levels of GD3 and 9-O-acetyl GD3. Ganglioside GM1 and alpha v integrin receptor were not specific to any histological subtype. The expression of ganglioside GM1 and GD3 was independent of cell-cycle phase. We conclude that GD3 and 9-O-acetyl GD3expression may be additional markers of the Small Cell Lung Cancer phenotype, but their significance is unknown. Therefore a characteristicganglioside pattern cannot be defined according to histological subtype. av integrin receptor expression is not unique to cells expressing GD3. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:59:48