Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TIME-COURSE OF 5-HT2A RECEPTOR OCCUPANCY IN THE HUMAN BRAIN AFTER A SINGLE ORAL DOSE OF THE PUTATIVE ANTIPSYCHOTIC DRUG MDL-100,907 MEASURED BY POSITRON EMISSION TOMOGRAPHY
Autore:
GRUNDER G; YOKOI F; OFFORD SJ; RAVERT HT; DANNALS RF; SALZMANN JK; SZYMANSKI S; WILSON PD; HOWARD DR; WONG DF;
Indirizzi:
JOHNS HOPKINS MED INST,JHOC,DEPT RADIOL,DIV NUCL MED,ROOM 3245,601 N CAROLINE ST BALTIMORE MD 21287 JOHNS HOPKINS MED INST,JHOC,DEPT RADIOL,DIV NUCL MED BALTIMORE MD 21287 UNIV MARYLAND,SCH MED,DEPT EPIDEMIOL & PREVENT MED BALTIMORE MD 21201 HOECHST MAR ROUSSEL CINCINNATI OH 00000
Titolo Testata:
Neuropsychopharmacology
fascicolo: 3, volume: 17, anno: 1997,
pagine: 175 - 185
SICI:
0893-133X(1997)17:3<175:TO5ROI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVING HUMAN-BRAIN; SEROTONIN RECEPTORS; DOPAMINE-RECEPTORS; CEREBRAL-CORTEX; CLOZAPINE; BINDING; INVIVO; PET; RADIOLIGAND; MDL-100,907;
Keywords:
POSITRON EMISSION TOMOGRAPHY; HUMAN; 5-HT2 RECEPTORS; MDL 100,907; ANTIPSYCHOTIC DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Grunder et al., "TIME-COURSE OF 5-HT2A RECEPTOR OCCUPANCY IN THE HUMAN BRAIN AFTER A SINGLE ORAL DOSE OF THE PUTATIVE ANTIPSYCHOTIC DRUG MDL-100,907 MEASURED BY POSITRON EMISSION TOMOGRAPHY", Neuropsychopharmacology, 17(3), 1997, pp. 175-185

Abstract

MDL 100,907 is a potent and selective antagonist of 5-HT2A serotonin receptors. Animal studies suggest that MDL 100,907 may behave as an atypical antipsychotic drug. Positron emission tomograph (PET) using [C-11]NMSP as the radiotracer was used to define the time course of 5-HT2receptor occupancy in the human frontal cerebral cortex after a single oral dose of MDL 100,907 (10 or 20 mg) in nine healthy subjects. After the baseline scan each subject was studied three times post dosing at various time points. 5-HT2 occupancies were in the range of 70 and 90% after each dose. While the occupancy remains in this range over 24hours after 20 mg MDL 100,907, it decreases by about 20% at 24 Hours compared to the timepoint at 8 hours, when only 10 mg are administered(p < 0.05). Our results should allow determination of the appropriatedosing regimen for future trials in schizophrenic patients. (C) 1997 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:25:03