Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
KETAMINE-INDUCED EXACERBATION OF PSYCHOTIC SYMPTOMS AND COGNITIVE IMPAIRMENT IN NEUROLEPTIC-FREE SCHIZOPHRENICS
Autore:
MALHOTRA AK; PINALS DA; ADLER CM; ELMAN I; CLIFTON A; PICKAR D; BREIER A;
Indirizzi:
NIMH,EXPT THERAPEUT BRANCH,INTRAMURAL RES PROGRAM,NIH,BLDG 10,ROOM 4N212,10 CTR DR BETHESDA MD 20892
Titolo Testata:
Neuropsychopharmacology
fascicolo: 3, volume: 17, anno: 1997,
pagine: 141 - 150
SICI:
0893-133X(1997)17:3<141:KEOPSA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE; MEMORY; ASPARTATE; RECEPTOR; NEURONS;
Keywords:
KETAMINE; NMDA; SCHIZOPHRENIA; COGNITION; PSYCHOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Malhotra et al., "KETAMINE-INDUCED EXACERBATION OF PSYCHOTIC SYMPTOMS AND COGNITIVE IMPAIRMENT IN NEUROLEPTIC-FREE SCHIZOPHRENICS", Neuropsychopharmacology, 17(3), 1997, pp. 141-150

Abstract

The N-methyl-d-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. We administered subanesthetic doses of the NMDA receptor antagonist ketamine in it double-blind, placebo-controlled design to 13 neuroleptic-free schizophrenic patients to investigate if schizophrenics will experience an exacerbation of psychotic symptoms and cognitive impairments with ketamine. We also examined whether schizophrenics experienced quantitative or qualitative differences in ketamine response in comparison to normal controls. Schizophrenics experienced a brief ketamine-induced exacerbation of positive and negative symptoms with further decrements in recall and recognition memory. They also displayed greater ketamine-induced impairments in free recall than normals. Qualitative differences included auditory hallucinations and paranoia in patients brit not in normals. These data indicate that ketamine is associated with exacerbation of core psychotic andcognitive symptoms in schizophrenia. Moreover, ketamine may differentially affect cognition in schizophrenics ii? comparison to normal cortrols. (C) 1997 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:25:28