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Titolo:
LATENCY AND REACTIVATION OF JC VIRUS IN PERIPHERAL-BLOOD OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED PATIENTS
Autore:
DUBOIS V; DUTRONC H; LAFON ME; POINSOT V; PELLEGRIN JL; RAGNAUD JM; FERRER AM; FLEURY HJA;
Indirizzi:
UNIV BORDEAUX 2,VIROL LAB,INST FEDERAT RECH PATHOL INFECT,146 RUE LEOSAIGNAT F-33076 BORDEAUX FRANCE UNIV BORDEAUX 2,VIROL LAB,INST FEDERAT RECH PATHOL INFECT F-33076 BORDEAUX FRANCE CTR HOSP UNIV,HOP PELLEGRIN,SERV MED INTERNE BORDEAUX FRANCE CTR HOSP UNIV,HOP PELLEGRIN,SERV PATHOL INFECT BORDEAUX FRANCE CTR HOSP UNIV,HOP HAUT LEVEQUE,SERV MED INTERNE BORDEAUX FRANCE CTR HOSP UNIV,HOP HAUT LEVEQUE,SERV PATHOL INFECT BORDEAUX FRANCE ETAB TRANSFUS SANGUINE AQUITAINE BORDEAUX FRANCE
Titolo Testata:
Journal of clinical microbiology
fascicolo: 9, volume: 35, anno: 1997,
pagine: 2288 - 2292
SICI:
0095-1137(1997)35:9<2288:LAROJV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; POLYMERASE CHAIN-REACTION; POLYOMAVIRUS INFECTION; BRAIN-TISSUE; BONE-MARROW; BK-VIRUS; DNA; PATHOGENESIS; PREVALENCE; EXCRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
V. Dubois et al., "LATENCY AND REACTIVATION OF JC VIRUS IN PERIPHERAL-BLOOD OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED PATIENTS", Journal of clinical microbiology, 35(9), 1997, pp. 2288-2292

Abstract

JC virus (JCV) acts as an opportunistic virus in immunocompromised human immunodeficient virus type 1 (HIV-1)-infected patients, The role of peripheral blood cells in central nervous system invasion, before the onset of progressive multifocal leukoencephalopathy (PML, remains controversial, In order to clarify JCV latency or reactivation status inperipheral blood, 72 HIV-1-infected patients were studied, together with 7 HIV-1-positive PML patients and 50 blood donors, Blood leukocytes, plasma, and B lymphocytes were investigated by two complementary DNA amplification procedures within the early T and late VP1 JCV genes and two reverse transcription techniques for the detection of corresponding early transcripts and mRNAs. JCV DNA was detected in 40.3% of theHIV-1-infected patients but only 8% of the blood donors (P < 0.001), Leukocytes represented 82.7% of the positive samples, but plasma from 12 patients (41.4%) contained JCV DNA. B lymphocytes seemed to be involved in the natural history of JCV but did not represent the unique cell target, JCV DNA was intermittently found in blood, and JCV mRNAs for VPI capsid protein were detected exclusively in one PML patient. Such observations demonstrate that JCV, when detected in blood, does-not undergo active multiplication. They support the JCV hematogenous spread hypothesis, but do not indicate any direct link between peripheral virus and dissemination in the central nervous system at the time of immunodepression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:10:42