Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPARISON OF THE HYBRID CAPTURE TUBE TEST AND PCR FOR DETECTION OF HUMAN-PAPILLOMAVIRUS DNA IN CERVICAL SPECIMENS
Autore:
COPE JU; HILDESHEIM A; SCHIFFMAN MH; MANOS MM; LORINCZ AT; BURK RD; GLASS AG; GREER C; BUCKLAND J; HELGESEN K; SCOTT DR; SHERMAN ME; KURMAN RJ; LIAW KL;
Indirizzi:
NCI,DIV CANC EPIDEMIOL & GENET,EPN RM 439 BETHESDA MD 20892 DIGENE CORP SILVER SPRING MD 00000 INFORMAT MANAGEMENT SERV INC SILVER SPRING MD 00000 KAISER PERMANENTE NO CALIF OAKLAND CA 00000 JOHNS HOPKINS UNIV HOSP BALTIMORE MD 21287 ALBERT EINSTEIN COLL MED NEW YORK NY 00000 KAISER PERMANENTE PORTLAND OR 00000 CHIRON CORP EMERYVILLE CA 94608
Titolo Testata:
Journal of clinical microbiology
fascicolo: 9, volume: 35, anno: 1997,
pagine: 2262 - 2265
SICI:
0095-1137(1997)35:9<2262:COTHCT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAEPITHELIAL NEOPLASIA; INFECTION; RISK; DIAGNOSIS; CANCER; CELLS; HYBRIDIZATION; POPULATION; COLOMBIA; SPAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.U. Cope et al., "COMPARISON OF THE HYBRID CAPTURE TUBE TEST AND PCR FOR DETECTION OF HUMAN-PAPILLOMAVIRUS DNA IN CERVICAL SPECIMENS", Journal of clinical microbiology, 35(9), 1997, pp. 2262-2265

Abstract

The strong association of human papillomavirus (HPV) and cervical cancer makes it important to study NPV detection methods that may play a role In cervical cancer screening. We compared two DNA methods that are commonly used for HPV research in the United States: the MY09/MY11 L1 consensus primer PCR-based test and the first-generation Hybrid Capture tube method (HCT). Laboratory assays by each method were performedwith 596 cervicovaginal specimens collected from participants in a large cohort study conducted in Portland, Oreg, Included were 499 specimens from women whose cytology was normal and 97 specimens from women with squamous intraepithelial lesions (SILs). The overall HPV DNA positivity for known types was 22.5% by PCR compared to 13.6% by BCT. When the analysis nas restricted to the 14 HPV types detectable by both methods, the sensitivity of HCT, with PCR used as the standard for HPV status, was higher for specimens from women with concurrent SILs (81.0%)than for specimens from women with normal cytology (46.7%), Among specimens testing positive by both methods, 97.2% of the time the two methods agreed on whether specimens were positive for cancer-associated HPV types. Both of these HPV test methods provide information that supplements the information provided by the Pap smear. The PCR method has higher analytic sensitivity than RCT in detecting HPV, but HCT magi behelpful in identifying women with concurrent SILs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:35:30