Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
UP-REGULATION OF THE ELONGATION FACTOR-1-ALPHA GENE BY P53 IN ASSOCIATION WITH DEATH OF AN ERYTHROLEUKEMIC CELL-LINE
Autore:
KATO MV; SATO H; NAGAYOSHI M; IKAWA Y;
Indirizzi:
RIKEN,INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,ONCOL MOL LAB,3-1-1 KOYADAI TSUKUBA IBARAKI 305 JAPAN TOKYO MED & DENT UNIV,DEPT RETROVIRAL REGULAT,DIV MED RES TOKYO 113 JAPAN
Titolo Testata:
Blood
fascicolo: 4, volume: 90, anno: 1997,
pagine: 1373 - 1378
SICI:
0006-4971(1997)90:4<1373:UOTEFG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASES; TUMOR-SUPPRESSOR GENE; IN-VIVO; DNA-BINDING; BAX GENE; APOPTOSIS; EXPRESSION; INHIBITOR; PROTEIN; P21;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M.V. Kato et al., "UP-REGULATION OF THE ELONGATION FACTOR-1-ALPHA GENE BY P53 IN ASSOCIATION WITH DEATH OF AN ERYTHROLEUKEMIC CELL-LINE", Blood, 90(4), 1997, pp. 1373-1378

Abstract

Genes upregulated by p53 were screened using an erythroleukemic cell line (1-2-3) that expresses only the temperature-sensitive p53 by the mRNA differential display method. One of the upregulated genes was identified as the elongation factor-1 alpha (EF-1 alpha) gene, an essential component of the eukaryotic translation apparatus, Three p53-responsive elements were found in the mouse EF-1 alpha gene and in the corresponding human, rat, and frog genes. These elements conferred the capacity for induction by p53. EF-1 alpha is also a microtubule-severing protein. Upon the temperature-shift, the cells developed the morphologyand the localization of alpha-tubulin similar to those of the cells treated with vincristine, a drug that affects microtubules. The microtubule-severing associated with upregulation of EF-1 alpha by p53 may bea cause of the cell death. (C) 1997 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:40:41