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Titolo:
CEREBRAL ANGIOGENESIS TRIGGERED BY SEVERE CHRONIC HYPOXIA DISPLAYS REGIONAL DIFFERENCES
Autore:
PATT S; SAMPAOLO S; THEALLIERJANKO A; TSCHAIRKIN I; CERVOSNAVARRO J;
Indirizzi:
UNIV JENA,INST PATHOL NEUROPATHOL D-07740 JENA GERMANY FREE UNIV BERLIN,INST NEUROPATHOL D-1000 BERLIN GERMANY UNIV JENA,INST PATHOL NEUROPATHOL D-07740 JENA GERMANY
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 7, volume: 17, anno: 1997,
pagine: 801 - 806
SICI:
0271-678X(1997)17:7<801:CATBSC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOBARIC HYPOXIA; BRAIN; RATS; CAPILLARY; SKELETAL; MUSCLE;
Keywords:
CHRONIC HYPOXIA; RAT; CNS; ANGIOGENESIS; BLOOD VESSELS; MORPHOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Patt et al., "CEREBRAL ANGIOGENESIS TRIGGERED BY SEVERE CHRONIC HYPOXIA DISPLAYS REGIONAL DIFFERENCES", Journal of cerebral blood flow and metabolism, 17(7), 1997, pp. 801-806

Abstract

The blood vessels in the brains of adult rats subjected to chronic normobaric hypoxia and control animals housed under normoxic conditions were morphometrically studied. Hypoxic male inbred Wistar rats were exposed over a period of 130 days to decreasing amounts of oxygen starting from 21% down to 7% (15%: 15 days; 12%, 10%, 8%: 22 days, respectively; 7%: 49 days). Areas of cerebral cortex, striatum, hippocampus, cerebellum, and medulla oblongata were investigated. The ratio vessel number per mm(2) tissue and the average vessel size were measured using a Quantimet Q570. In the hypoxic animals, cerebral cortex, striatum, and hippocampus showed a significant increase of the vessel density permm(2) tissue (P<0.01 or P<0.05). The differences in both groups were highest in the striatum and hippocampus. In the cerebellum and the medulla oblongata of hypoxic animals, only a tendency to higher vessel numbers per mm(2) tissue was found. The average brood vessel size differed only in the cerebral cortex and the cerebellum, but not in the other brain regions tested. The results indicate that the adaptation of the brain circulation to hypoxia is achieved by both angiogenesis and dilatation of microvessels, and that the pattern of the microcirculatorychanges is not homogenous in all regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:10:45