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Titolo:
A RANDOMIZED TRIAL OF SURGERY WITH AND WITHOUT CHEMOTHERAPY FOR LOCALIZED SQUAMOUS CARCINOMA OF THE THORACIC ESOPHAGUS - THE JAPAN CLINICALONCOLOGY GROUP-STUDY
Autore:
ANDO N; IIZUKA T; KAKEGAWA T; ISONO K; WATANABE H; IDE H; TANAKA O; SHINODA M; TAKIYAMA W; ARIMORI M; ISHIDA K; TSUGANE S;
Indirizzi:
KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU TOKYO 160 JAPAN NATL OJI HOSP TOKYO JAPAN KURUME UNIV,FAC MED,DEPT SURG KURUME FUKUOKA 830 JAPAN CHIBA UNIV,FAC MED,DEPT SURG CHIBA JAPAN NATL CANC CTR,DEPT SURG TOKYO JAPAN TOKYO WOMENS MED COLL,DEPT SURG TOKYO 162 JAPAN NIIGATA UNIV,FAC MED,DEPT SURG NIIGATA JAPAN AICHI CANC CTR HOSP,DEPT THORAC SURG NAGOYA AICHI 464 JAPAN NATL SHIKOKU CANC CTR HOSP,DEPT SURG MATSUYAMA EHIME JAPAN TOKYO NATL HOSP 2,DEPT SURG TOKYO JAPAN IWATE MED COLL,DEPT SURG MORIOKA IWATE JAPAN NATL CANC CTR RES INST E,EPIDEMIOL & BIOSTAT DIV CHIBA JAPAN
Titolo Testata:
Journal of thoracic and cardiovascular surgery
fascicolo: 2, volume: 114, anno: 1997,
pagine: 205 - 209
SICI:
0022-5223(1997)114:2<205:ARTOSW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE-II EVALUATION; CELL CARCINOMA; 3-FIELD LYMPHADENECTOMY; CANCER; CISPLATIN; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
N. Ando et al., "A RANDOMIZED TRIAL OF SURGERY WITH AND WITHOUT CHEMOTHERAPY FOR LOCALIZED SQUAMOUS CARCINOMA OF THE THORACIC ESOPHAGUS - THE JAPAN CLINICALONCOLOGY GROUP-STUDY", Journal of thoracic and cardiovascular surgery, 114(2), 1997, pp. 205-209

Abstract

Objective: To determine whether postoperative adjuvant chemotherapy confers a survival benefit on patients with esophageal squamous cell carcinoma undergoing radical surgery, we undertook a cooperative, prospective randomized controlled trial. Methods: A total of 205 patients underwent transthoracic esophagectomy with lymphadenectomy at eleven institutions between December 1988 and July 1991. These patients were prospectively randomized into two groups (100 patients underwent surgery alone and 105 patients had additional two courses of combination chemotherapy with cisplatin (70 mg/m(2)) and vindesine (3 mg/m(2)). The twogroups did not differ with respect to sex, age, location of tumor, and distributions of pT, pN, pM, or p stage, Results: The 5-year survival was 44.9% in the surgery alone group and 48.1% in the surgery plus chemotherapy group. The relative risk was estimated to be 0.89 (95% confidence interval, 0.61 to 1.31) in the surgery plus chemotherapy groupcompared with the surgery alone group. No significant differences in survival were detected between the two groups, even with lymph node stratification. Conclusion: Postoperative adjuvant chemotherapy with cisplatin and vindesine has no additive effect on survival in patients with esophageal cancer compared with surgery alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:07:13