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Titolo:
GLUCOSE-INSULIN-POTASSIUM THERAPY FOR TREATMENT OF ACUTE MYOCARDIAL-INFARCTION - AN OVERVIEW OF RANDOMIZED PLACEBO-CONTROLLED
Autore:
FATHORDOUBADI F; BEATT KJ;
Indirizzi:
HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,MRC,CTR CLIN SCI LONDON W12 0HS ENGLAND HAMMERSMITH HOSP,DEPT CARDIOL LONDON W12 0HS ENGLAND
Titolo Testata:
Circulation
fascicolo: 4, volume: 96, anno: 1997,
pagine: 1152 - 1156
SICI:
0009-7322(1997)96:4<1152:GTFTOA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE FATTY-ACIDS; CORONARY REPERFUSION; ISCHEMIA; ARRHYTHMIAS; INHIBITION; HYPOXIA; CONTRACTILITY; HEMODYNAMICS; METABOLISM; GLYCOLYSIS;
Keywords:
GLUCOSE; MYOCARDIAL INFARCTION; INSULIN; METABOLISM; METAANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
F. Fathordoubadi e K.J. Beatt, "GLUCOSE-INSULIN-POTASSIUM THERAPY FOR TREATMENT OF ACUTE MYOCARDIAL-INFARCTION - AN OVERVIEW OF RANDOMIZED PLACEBO-CONTROLLED", Circulation, 96(4), 1997, pp. 1152-1156

Abstract

Background Glucose-insulin-potassium (GIK) therapy has been advocatedfor the treatment of acute myocardial infarction. However, the results from the clinical trials have been inconclusive, largely because of the small number of patients recruited and discrepancies between protocols used in these studies. Method and Results A systematic MEDLINE search fur all the randomized placebo-controlled studies of GIK therapy in acute myocardial infarction was made, and a meta-analysis of the mortality data was performed. Fifteen trials were identified, 5 were excluded because of poor randomization, and 1 was excluded because recruitment was limited to diabetic patients. The 9 remaining trials with a total of 1932 patients were included in the analysis. Hospital mortality was reduced from 21% (205 of 972 patients) in the placebo group to 16.1% (154 of 956) in the GIK group (P = .004; odds ratio, 0.72: 95% confidence interval [CI], 0.57 to 0.90). The proportional mortality reduction was 28% (CI, 10% to 43%). The number of lives saved per 1000 patients treated was 49 (95% CI, 14 to 83). Conclusions The findings indicate that GIK therapy may have an important role in reducing the in-hospital mortality after acute myocardial infarction. The value of thistherapy in the era of thrombolysis and acute revascularization by primary angioplasty can be fully resolved only by conducting a large randomized mortality study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:36:08