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Titolo:
EFFECTS OF DIETHYLAMINE NITRIC-OXIDE ON BLOOD PERFUSION AND OXYGENATION IN THE R3230AC MAMMARY-CARCINOMA
Autore:
SHAN SQ; ROSNER GL; BRAUN RD; HAHN J; PEARCE C; DEWHIRST MW;
Indirizzi:
DUKE UNIV,MED CTR,DEPT RADIAT ONCOL,BOX 3455 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT RADIAT ONCOL DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT COMMUNITY & FAMILY MED,DIV BIOMETRY DURHAM NC 27710
Titolo Testata:
British Journal of Cancer
fascicolo: 4, volume: 76, anno: 1997,
pagine: 429 - 437
SICI:
0007-0920(1997)76:4<429:EODNOB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL TISSUE MICROVASCULATURE; SYNTHASE INHIBITOR; RECESSED CATHODE; SKELETAL-MUSCLE; MURINE TUMORS; L-ARGININE; HYPOXIA; FLOW; HEMODYNAMICS; METABOLISM;
Keywords:
DEA/NO; NITRIC OXIDE; TUMOR BLOOD FLOW; ARTERIOLAR DIAMETER; VASOMOTION; TUMOR OXYGENATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S.Q. Shan et al., "EFFECTS OF DIETHYLAMINE NITRIC-OXIDE ON BLOOD PERFUSION AND OXYGENATION IN THE R3230AC MAMMARY-CARCINOMA", British Journal of Cancer, 76(4), 1997, pp. 429-437

Abstract

The effects of intravenous diethylamine/nitric oxide (DEA/NO), a short-acting nitric oxide (NO) donor, on systemic haemodynamics, muscle and tumour blood flow (MBF and TBF) and tumour oxygenation were examinedin rats bearing subcutaneous R3230Ac carcinoma in the leg. The effects of DEA/NO on the diameters of tumour-feeding and normal arterioles were evaluated in window chambers with and without implanted tumours. DEA\NO reduced mean arterial pressure (MAP) when given at doses greaterthan or equal to 100 nmol kg(-1), with maximal suppression at 0.5-1 min followed by return to baseline within 20 min. DEA/NO did not affectMBF except at the highest doses (500 and 1000 nmol kg(-1)). In contrast, DEA/NO reduced TBF and constricted tumour arterioles at doses greater than or equal to 100 nmol kg(-1). Tumour arteriolar vasomotion occurred in more than half the animals during hypotension and with a significantly higher frequency than in normal granulating tissue at a doseof 500 nmol kg(-1), Normal arterioles rapidly and significantly vasodilated for about 3 min and then returned to baseline, The reductions in TBF and MAP were accompanied by synchronous reduction in tumour pO(2). Our findings suggest that DEA/NO decreases TBF in two ways. In the window chamber model, vascular steal occurs as normal arterioles adjacent to tumour dilate more than tumour arterioles during the initial period of hypotension. In leg tumours, the predominant mechanism is attributable to reduced perfusion pressure induced by lowered MAP, which decreases flow to the tumour, probably because of relatively higher flow resistance. The vasoconstriction and vasomotion in tumour arteriolesduring DEA/NO-induced hypotension may reflect differences in regulatory metabolism of NO between neoplastic and normal arterioles. Thus, intravenous injection of a short-acting NO donor, DEA/NO, decreases MAP and heart rate, leading to subsequent decreases in tumour blood flow and oxygenation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:50:31