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Titolo:
DIFFERENTIAL EXPRESSION OF THE GROWTH-HORMONE RECEPTOR AND ITS TRANSCRIPT IN BOVINE UTERUS AND PLACENTA
Autore:
KOLLE S; SINOWATZ F; BOIE G; LINCOLN D; WATERS MJ;
Indirizzi:
UNIV MUNICH,DEPT VET ANAT,VETERINARSTR 13 D-80539 MUNICH GERMANY KUWAIT UNIV,FAC ALLIED HLTH SCI SAFAT 13060 KUWAIT UNIV QUEENSLAND,DEPT PHYSIOL & PHARMACOL ST LUCIA QLD 4072 AUSTRALIA
Titolo Testata:
Molecular and cellular endocrinology
fascicolo: 2, volume: 131, anno: 1997,
pagine: 127 - 136
SICI:
0303-7207(1997)131:2<127:DEOTGR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH-BINDING-PROTEIN; PRENATAL EXPRESSION; PROLACTIN RECEPTOR; MOLECULAR-CLONING; MESSENGER-RNA; SOMATOMEDIN-C; RAT; FETAL; SERUM; LOCALIZATION;
Keywords:
GROWTH HORMONE RECEPTOR; UTERUS; PLACENTA (BOVINE);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
S. Kolle et al., "DIFFERENTIAL EXPRESSION OF THE GROWTH-HORMONE RECEPTOR AND ITS TRANSCRIPT IN BOVINE UTERUS AND PLACENTA", Molecular and cellular endocrinology, 131(2), 1997, pp. 127-136

Abstract

By reverse transcription-polymer-ase chain reaction (RT-PCR) the transcript of the growth hormone receptor (GHR) was proved in bovine placentae of different gestational stages. Using non-radioactive in situ hybridization (ISH) the mRNA encoding GHR was localized in the uterine epithelium, glands, vessels and amniochorion of the placenta from the sixth week until the ninth month of gestation. Production of mRNA was low during the first trimester, significantly increased in the second trimester and peaked at the end of the sixth month of pregnancy. No transcript of GHR was found in the endometrium of non-pregnant uteri. Thecolocalization of the protein using a monoclonal antibody showed the same distribution pattern as the mRNA. Immunoblotting revealed a protein with a molecular weight of 120 kDa in the endometrium of pregnant cows which was not found in non-pregnant uteri. Our results imply that growth hormone is involved in placental metabolism and embryonic development from the early beginning of pregnancy until birth. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 12:53:36