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Titolo:
DOBUTAMINE IMPROVES GASTROINTESTINAL MUCOSAL BLOOD-FLOW IN A PORCINE MODEL OF ENDOTOXIC-SHOCK
Autore:
NEVIERE R; CHAGNON JL; VALLET B; LEBLEU N; MARECHAL X; MATHIEU D; WATTEL F; DUPUIS B;
Indirizzi:
CTR HOSP REG & UNIV LILLE,HOP CALMETTE,SERV REANIMAT MED & MED HYPERBARE,PL VERDUN F-59037 LILLE FRANCE CTR HOSP REG & UNIV LILLE,HOP HURIEZ,DEPT ANESTHESIE REANIMAT CHIRURGF-59037 LILLE FRANCE UNIV MED,SERV PHARMACOL FONDAMENTALE LILLE FRANCE
Titolo Testata:
Critical care medicine
fascicolo: 8, volume: 25, anno: 1997,
pagine: 1371 - 1377
SICI:
0090-3493(1997)25:8<1371:DIGMBI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI SEPSIS; LASER DOPPLER FLOWMETRY; INTRAMUCOSAL PH; TISSUE OXYGENATION; CARDIOGENIC-SHOCK; HEMORRHAGIC-SHOCK; SMALL-INTESTINE; GASTRIC-MUCOSA; INTRAMURAL PH; GUT ISCHEMIA;
Keywords:
ANIMAL MODEL; ENDOTOXIN; SEPSIS; INTESTINAL MUCOSA; SPLANCHNIC PERFUSION; PH; TONOMETRY; ACIDOSIS; MICROCIRCULATION; BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R. Neviere et al., "DOBUTAMINE IMPROVES GASTROINTESTINAL MUCOSAL BLOOD-FLOW IN A PORCINE MODEL OF ENDOTOXIC-SHOCK", Critical care medicine, 25(8), 1997, pp. 1371-1377

Abstract

Objective: To test the hypothesis that saline solution plus dobutamine increases gastrointestinal mucosal perfusion better than saline solution alone in a model of endotoxic shock. Design: Prospective, randomized, unblinded study. Setting: Animal research laboratory affiliated with a university teaching hospital. Subjects: Twelve female pigs, weighing 30 to 32 kg. Interventions: Animals were anesthetized, and their lungs were mechanically ventilated, Catheters were inserted into the right atrium, pulmonary artery, and carotid artery for blood sampling and blood pressure and cardiac output measurements, A tonometer and a laser Doppler probe were placed in the lumen of the stomach and the ileum for determination of mucosal acid base status and measurement of mucosal blood flow, Group 1 animals (n = 6) received an infusion (T = 0 min) of 150 mu g/kg Escherichia coli endotoxin and normal saline solution (0.3 mL/kg/min), Group 2 animals (n = 6) received an infusion of endotoxin and were resuscitated with the same method as used in group 1, but an infusion of dobutamine (5 mu g/kg/min) was begun at T = 60 mins, and continued for the duration of the experiment. Measurements andMain Results: Both experimental regimens produced shock, with decreased mean arterial pressure and systemic vascular resistance, without change in cardiac output and oxygen delivery, Endotoxin plus saline infusion decreased gastrointestinal mucosal blood flow to <60% of baselineand decreased gastrointestinal pH. In contrast, gastrointestinal mucosal blood flow returned to baseline values, and intramucosal pH tendedto normalize by the end of the saline solution plus dobutamine resuscitative protocol. Conclusion: Compared with saline solution alone, saline solu- tion plus dobutamine increased blood flow to the gastrointestinal mucosa, and may have partially improved oxygenation.

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Documento generato il 09/07/20 alle ore 17:38:37