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Titolo:
EFFECT OF CLASSIC HEATSTROKE ON SERUM PROCALCITONIN
Autore:
NYLEN ES; ALARIFI A; BECKER KL; SNIDER RH; ALZEER A;
Indirizzi:
VET AFFAIRS MED CTR,DEPT MED,ENDOCRINOL SECT,50 IRVING ST NW WASHINGTON DC 20422 GEORGE WASHINGTON UNIV WASHINGTON DC 00000 KING FAISAL SPECIALIST HOSP & RES CTR,DEPT MED,ENDOCRINOL SECT RIYADH11211 SAUDI ARABIA KING KHALID UNIV HOSP,DEPT MED,PULM & CRIT CARE MED SECT RIYADH 11472SAUDI ARABIA
Titolo Testata:
Critical care medicine
fascicolo: 8, volume: 25, anno: 1997,
pagine: 1362 - 1365
SICI:
0090-3493(1997)25:8<1362:EOCHOS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-STROKE; SEPSIS; ENDOTOXIN; INFECTION; CYTOKINE; RELEASE;
Keywords:
HEAT STROKE; COOLING TIME; SERUM PROCALCITONIN; APACHE II; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E.S. Nylen et al., "EFFECT OF CLASSIC HEATSTROKE ON SERUM PROCALCITONIN", Critical care medicine, 25(8), 1997, pp. 1362-1365

Abstract

Objective: Procalcitonin, the precursor peptide of calcitonin, has been shown to be a serum marker of the severity and mortality of severalsystemic inflammatory response syndromes, This study addressed the correlation of serum procalcitonin with the course of classic (nonexertional) heatstroke. Design: Serum samples were collected prospectively every 6 hrs for 24 hrs. Setting: Heatstroke treatment unit, Makkah, Saudi Arabia. Patients: A total of 25 patients were admitted during the annual Hajj pilgrimage in 1994, Ten patients evaluated in the same treatment center with minor illnesses and without pyrexia served as controls. Interventions: Patients were cooled according to an established evaporation method. Measurements and Main Results: Standard critical care parameters including continuous rectal temperature, A rapid immunochemical assay for serum procalcitonin was utilized. The mean serum procalcitonin was elevated 20-fold on admission in patients with heatstroke compared with controls (p <.011), The procalcitonin concentration subsequently increased to a pla teau by 6 hrs and remained increased at 24 hrs, compared with the admission level (p <.0001), In this study, 77% of the patients with heatstroke survived, A subgroup analysis demonstrated that the patients who survived had a significantly higher procalcitonin concentration than those patients who died of heatstroke; a procalcitonin concentration of >0.5 ng/mL (>0.15 nmol/L) at 6 hrs predicted survival (p =.02). Conclusion: Classic heatstroke is associated with increased concentrations of serum procalcitonin, particularly among survivors, Further studies are required to elucidate the source andaction(s) of procalcitonin as well as its relationship to cytokine activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:51:06