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Titolo:
THE INFLUENCE OF A NOVEL PENTADECAPEPTIDE, BPC-157, ON N-G-NITRO-L-ARGININE METHYLESTER AND L-ARGININE EFFECTS ON STOMACH MUCOSA INTEGRITY AND BLOOD-PRESSURE
Autore:
SIKIRIC P; SEIWERTH S; GRABAREVIC Z; RUCMAN R; PETEK M; JAGIC V; TURKOVIC B; ROTKVIC I; MISE S; ZORICIC I; KONJEVODA P; PEROVIC D; JURINA L; SEPAROVIC J; HANZEVACKI M; ARTUKOVIC B; BRATULIC M; TISLJAR M; GJURASIN M; MIKLIC P; STANCICROKOTOV D; SLOBODNJAK Z; JELOVAC N; MAROVIC A;
Indirizzi:
UNIV ZAGREB,FAC MED,CTR DIGEST DIS,POB 916,SALATA 11 ZAGREB 10000 CROATIA UNIV ZAGREB,MED & VET FAC ZAGREB 10000 CROATIA
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 332, anno: 1997,
pagine: 23 - 33
SICI:
0014-2999(1997)332:1<23:TIOANP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-MUCOSA; OXIDE; INJURY; INHIBITORS; PEPTIDE; RAT;
Keywords:
PENTADECAPEPTIDE BPC 157; PEPTIDE BPC; NITRIC OXIDE (NO); GASTROINTESTINAL MUCOSAL INTEGRITY; BLOOD PRESSURE MAINTENANCE; GASTRIC LESION; HYPOTENSION; N-G-NITRO-L-ARGININE METHYLESTER; L-ARGININE; STOMACH MUCOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
P. Sikiric et al., "THE INFLUENCE OF A NOVEL PENTADECAPEPTIDE, BPC-157, ON N-G-NITRO-L-ARGININE METHYLESTER AND L-ARGININE EFFECTS ON STOMACH MUCOSA INTEGRITY AND BLOOD-PRESSURE", European journal of pharmacology, 332(1), 1997, pp. 23-33

Abstract

The known effects of a novel stomach pentadecapeptide BPC157 (10 mu gor 10 ng/kg), namely its salutary activity against ethanol (96%, i.g.)-induced gastric lesions (simultaneously applied i.p.) and in blood pressure maintenance (given i.v.), were investigated in rats challengedwith a combination of N-G-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v. ) (D-arginine wasineffective). In the gastric lesions assay, NO agents were given 5 min before ethanol injury and BPC 157 medication. Given alone, BPC157 had an antiulcer effect, as did L-arginine, but L-NAME had no effect. L-NAME completely abolished the effect of L-arginine, whereas it only attenuated the effect of BPC 157. After application of the combination of L-NAME + L-arginine, the BPC157 effect was additionally impaired. Inblood pressure studies, compared with L-arginine, pentadecapeptide BPC 157 (without effect on basal normal values) had both a mimicking effect (impaired L-NAME-blood pressure increase, when applied prophylactically and decreased already raised L-NAME values, given at the time ofthe maximal L-NAME-blood pressure increase (i.e., 10 min after L-NAME)) and preventive activity (L-arginine-induced moderate blood pressuredecrease was prevented by BPC 157 pretreatment). When BPC 157 was given 10 min after L-NAME + L-arginine combination, which still led to a blood pressure increase, its previously clear effect (noted in L-NAME treated rats) disappeared. In vitro, in gastric mucosa from rat stomach tissue homogenates, BPC 157, given in the same dose (100 mu M) as L-arginine, induced a comparable generation of NO. But, BPC 157 effect could not be inhibited by L-NAME, even when L-NAME was given in a tenfold (100 versus 1000 mu M) higher dose than that needed for inhibition of the L-arginine effect. NO synthesis was blunted when the pentadecapeptide BPC 157 and L-arginine were combined. In summary, BPC 157 couldinterfere with the effects of NO on both gastric mucosal integrity and blood pressure maintenance in a specific way, especially with L-arginine, having a more prominent and/or particularly different effect from that of NO. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:40:05