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Titolo:
SHORT-TERM AND LONG-TERM FOLLOW-UP OF THYROID-DYSFUNCTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION WITHOUT THE USE OF PREPARATIVE TOTAL-BODY IRRADIATION
Autore:
TOUBERT ME; SOCIE G; GLUCKMAN E; ARACTINGI S; ESPEROU H; DEVERGIE A; RIBAUD P; PARQUET N; SCHLAGETER MH; BERESSI JP; RAIN JD; VEXIAU P;
Indirizzi:
HOP ST LOUIS,SERV GREFFE MOELLE,BONE MARROW TRANSPLANT UNIT,1 AVE CLAUDE VELLEFAUX F-75475 PARIS 10 FRANCE HOP ST LOUIS,SERV GREFFE MOELLE,BONE MARROW TRANSPLANT UNIT F-75475 PARIS 10 FRANCE HOP ST LOUIS,DEPT NUCL MED F-75475 PARIS 10 FRANCE HOP ST LOUIS,DEPT DERMATOL F-75475 PARIS 10 FRANCE HOP ST LOUIS,DEPT ENDOCRINOL & DIABETOL F-75475 PARIS 10 FRANCE
Titolo Testata:
British Journal of Haematology
fascicolo: 2, volume: 98, anno: 1997,
pagine: 453 - 457
SICI:
0007-1048(1997)98:2<453:SALFOT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOID-LEUKEMIA; ENDOCRINE FUNCTION; RANDOMIZED TRIAL; BUSULFAN-CYTOXAN; CYCLOPHOSPHAMIDE; CHILDREN; THERAPY; DISEASE; HEPATITIS; REGIMEN;
Keywords:
BONE MARROW TRANSPLANTATION; THYROID DYSFUNCTION; CHEMOTHERAPY; TOTAL BODY IRRADIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Toubert et al., "SHORT-TERM AND LONG-TERM FOLLOW-UP OF THYROID-DYSFUNCTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION WITHOUT THE USE OF PREPARATIVE TOTAL-BODY IRRADIATION", British Journal of Haematology, 98(2), 1997, pp. 453-457

Abstract

We studied the incidence and potential prognostic value of thyroid abnormalities after allogeneic bone marrow transplantation (BMT) withouttotal body irradiation (TBI) conditioning, 77 consecutive patients who received a chemotherapy-alone-based conditioning regimen pretransplant were included. Free serum thyroxine (FT4), free serum triiodothyronine (FT3) and serum thyrotropin (TSH) levels were assayed before and 3and 14 months after BMT. Patients were classified in three categories: normal thyroid profile if FT3 and FT4 were within the normal range and TSH was normal or low, peripheral thyroid insufficiency (PTI) if TSH was >4 mIU/I, or an 'euthyroid sick syndrome' (ETS) if FT3 and/or FT4 were low and TSH was normal or low, The incidence of thyroid dysfunction at 3 months was 57%, and 29% at 14 months. This was mostly due tothe occurrence of ETS which was more frequent at 3 months (48%, 29/61)than at 14 months (19%, 9/48), Furthermore, at 3 months, survival wassignificantly lower in the ETS group (34.5%) than in the euthyroid group (96:2%), or in the PTI group (83.3%) (P < 0.0001). PTI was observed even in the absence of TBI in 11 patients (14%) and was equally distributed at 3 months (n = 6) and 14 months (n = 5), In conclusion, thyroid dysfunction is not a rare complication even without pretransplant TBI conditioning regimen. Hypothyroidism prevalence was 10%, and ETS, which was more frequently observed, displayed a dismal predictive value at 3 months.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:04:20