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Titolo:
BETA(3)-ADRENERGIC RECEPTOR GENE POLYMORPHISM IS NOT A MAJOR GENETIC DETERMINANT OF OBESITY AND DIABETES IN JAPANESE GENERAL-POPULATION
Autore:
YUAN XH; YAMADA K; KOYAMA K; ICHIKAWA F; ISHIYAMA S; KOYANAGI A; KOYAMA W; NONAKA K;
Indirizzi:
KURUME UNIV,SCH MED,DEPT MED,DIV ENDOCRINOL & METAB,67 ASAHIMACHI KURUME FUKUOKA 830 JAPAN KURUME UNIV,SCH MED,DEPT MED,DIV ENDOCRINOL & METAB KURUME FUKUOKA 830 JAPAN KUMAMOTO RED CROSS,HLTH CARE CTR KUMAMOTO JAPAN
Titolo Testata:
Diabetes research and clinical practice
fascicolo: 1, volume: 37, anno: 1997,
pagine: 1 - 7
SICI:
0168-8227(1997)37:1<1:BRGPIN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENOCEPTOR AGONIST; ADIPOSE-TISSUE; BROWN FAT; WHITE; MICE; ANTIOBESITY; CL-316,243; GLUCOSE;
Keywords:
BETA(3)-ADRENERGIC RECEPTOR; OBESITY; IMPAIRED GLUCOSE TOLERANCE; VISCERAL FAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
X.H. Yuan et al., "BETA(3)-ADRENERGIC RECEPTOR GENE POLYMORPHISM IS NOT A MAJOR GENETIC DETERMINANT OF OBESITY AND DIABETES IN JAPANESE GENERAL-POPULATION", Diabetes research and clinical practice, 37(1), 1997, pp. 1-7

Abstract

To assess the contribution of a replacement of Trp at codon 64 of beta(3)-adrenergic receptor by Arg to fat distribution and metabolic disturbances in Japanese general population, we examined the missense mutation in 1122 persons consisting of 817 men aged 50.0 +/- 8.9 years and305 women aged 50.8 +/- 8.5 years in Kyushu, Japan. The incidence of Arg64 allele was 0.21; no age-dependent decrease of the allele frequency was observed, suggesting that the mutation was not associated with early mortality. The genotype was not significantly correlated with body mass index or the thickness of visceral fat estimated by ultrasonography. Glucose tolerance and glucose-induced insulin secretion were not significantly different among subjects with Trp/Trp, Trp/Arg and Arg/Arg at codon 64. Although in obese persons the ratio of heterozygotesfor the mutation tended to be higher in subjects with impaired glucose tolerance than in subjects with normal glucose tolerance, the tendency was not observed in non-obese persons. Furthermore none of 39 non-obese individuals homozygous for the mutation was diabetic, whereas twoout of six obese homozygous persons were diabetic. These observationssuggest that the missense mutation may not be a main determinant of obesity in populations taking low fat/low energy Japanese-style diet and it may not be deleterious at least in non-obese individuals. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:27:39