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Titolo:
ALTERED VENTRICULAR REPOLARIZATION DURING HYPOGLYCEMIA IN PATIENTS WITH DIABETES
Autore:
MARQUES JBL; GEORGE E; PEACEY SR; HARRIS ND; MACDONALD IA; COCHRANE T; HELLER SR;
Indirizzi:
NO GEN HOSP,CTR DIABET,HERRIES RD SHEFFIELD S5 7AU S YORKSHIRE ENGLAND ROYAL HALLAMSHIRE HOSP,DEPT MED PHYS & CLIN ENGN SHEFFIELD S10 2JF S YORKSHIRE ENGLAND
Titolo Testata:
Diabetic medicine
fascicolo: 8, volume: 14, anno: 1997,
pagine: 648 - 654
SICI:
0742-3071(1997)14:8<648:AVRDHI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-INDUCED HYPOGLYCEMIA; QT INTERVAL PROLONGATION; NOCTURNAL HYPOGLYCEMIA; BED SYNDROME; ARRHYTHMIA; SYSTEM; DEAD;
Keywords:
IDDM; NIDDM; HYPOLYCAEMIA; ELECTROCARDIOGRAM, CATECHOLAMINES, QT INTERVAL, SUDDEN DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.B.L. Marques et al., "ALTERED VENTRICULAR REPOLARIZATION DURING HYPOGLYCEMIA IN PATIENTS WITH DIABETES", Diabetic medicine, 14(8), 1997, pp. 648-654

Abstract

There is circumstantial evidence implicating hypoglycaemia in the sudden overnight death of young patients with insulin-dependent (Type 1) diabetes mellitus (IDDM), the mechanism of which is unknown. We have investigated the effects of hypoglycaemia on the electrocardiogram in 15 patients with diabetes (8 with IDDM and 7 with NIDDM) using a high resolution computer-based system. Patients were randomized to either 2hof euglycaemia or hypoglycaemia (at around 3 mmol l(-1)) during the afternoon, using hyperinsulinaemic glucose clamps, the two visits separated by a period of at least 9 weeks. Corrected QT interval (QTc), plasma potassium, and adrenaline were measured at baseline and at 0, 60, and 120 min. The degree of QTc lengthening (from baseline) during clamped hypoglycaemia was greater compared to the euglycaemic control period in patients with IDDM (median{range} at 60 min, 156{8 to 258} vs 6{-3 to 28} ms, p < 0.02) and NIDDM (120 rain, 128{16 to 166} vs 4{-3 to169} ms, p < 0.05). The fall in plasma potassium was greater during clamped hypoglycaemia compared to euglycaemic in those with NIDDM (p < 0.03) but not in those with IDDM (p > 0.06). The rise in plasma adrenaline was greater during clamped hypoglycaemia in both groups (IDDM p <0.02, NIDDM p < 0.02) and there tvas a strong relationship between the rise in adrenaline and increase in QTc (r = 0.73, p < 0.0001). Thesedata demonstrate alteration of ventricular repolarization with lengthening of the QT interval during hypoglycaemia and suggest a possible mechanism by which hypoglycaemia could cause ventricular arrhythmias. (C) 1997 by John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:05:38