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Titolo: PROTEIN SEQUENCESTRUCTURE COMPATIBILITY CRITERIA IN TERMS OF STATISTICAL HYPOTHESISTESTING
Autore: SUNYAEV S; KUZNETSOV E; RODCHENKOV I; TUMANYAN V;
 Indirizzi:
 RUSSIAN ACAD SCI,VA ENGELHARDT MOL BIOL INST,32 VAVILOV STR MOSCOW 117984 RUSSIA RUSSIAN ACAD SCI,VA ENGELHARDT MOL BIOL INST MOSCOW 117984 RUSSIA RUSSIAN ACAD SCI,INST CONTROL SCI MOSCOW 117806 RUSSIA
 Titolo Testata:
 Protein engineering
fascicolo: 6,
volume: 10,
anno: 1997,
pagine: 635  646
 SICI:
 02692139(1997)10:6<635:PSCCIT>2.0.ZU;2M
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 AMINOACIDSEQUENCE; 3DIMENSIONAL STRUCTURE; STRUCTURE PREDICTION; RECOGNITION; FOLD; POTENTIALS;
 Keywords:
 INVERSE PROTEIN FOLDING; PROTEIN STRUCTURE PREDICTION; STATISTICAL HYPOTHESIS TESTING; STATISTICAL PATTERN RECOGNITION; THREADING;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Science Citation Index Expanded
 Citazioni:
 23
 Recensione:
 Indirizzi per estratti:



 Citazione:
 S. Sunyaev et al., "PROTEIN SEQUENCESTRUCTURE COMPATIBILITY CRITERIA IN TERMS OF STATISTICAL HYPOTHESISTESTING", Protein engineering, 10(6), 1997, pp. 635646
Abstract
The assignment of query protein sequences to probable folds in a threading approach is based on the statistical analysis (learning) of structural properties of amino acids in known protein structures. We formalize the recognition problem in terms of mathematical statistics, namely statistical hypothesis testing. Our general formulation leads to various mathematical forms of a decision rule function for evaluation ofthe quality of a sequencestructure fit. Three criteria were derived according to a likelihood ratio approach. Two Of them have new functional forms while the third happens to coincide with the mean force potential function previously derived under the additional assumption of the Boltzmann law New decision rule functions employ (i) the Parzen estimator of a probability density and (ii) the newly introduced nonparametric statistic with known asymptotic distribution. We compared criteria efficiency by a 'structure seeks sequence' search for three highlypopulated template folds through a query library of nonhomologous sequences of proteins with known 3D structure using residue accessibility as an environmental variable. Various criteria reflect different underlying statistical propositions and thus often recognize diverse correct sequencestructure matches. On the other hand, if an amino acid sequence is recognized as compatible with a template by each of three decision rules it appears that one can make a more reliable inference ofsequencestructure relationship since almost all false positives obtained by the three criteria differ.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:00:37