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Titolo:
MINIMAL TRUNCATION OF THE C-MYB GENE-PRODUCT IN RAPID-ONSET B-CELL LYMPHOMA
Autore:
JIANG WP; KANTER MR; DUNKEL I; RAMSAY RG; BEEMON KL; HAYWARD WS;
Indirizzi:
JOHNS HOPKINS UNIV,DEPT BIOL,3400 N CHARLES ST BALTIMORE MD 21218 JOHNS HOPKINS UNIV,DEPT BIOL BALTIMORE MD 21218 MEM SLOAN KETTERING CANC CTR,LAB MOL GENET & ONCOL NEW YORK NY 10021 LUDWIG INST CANC RES,MELBOURNE TUMOUR BIOL BRANCH PARKVILLE VIC 3050 AUSTRALIA
Titolo Testata:
Journal of virology
fascicolo: 9, volume: 71, anno: 1997,
pagine: 6526 - 6533
SICI:
0022-538X(1997)71:9<6526:MTOTCG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
AVIAN-LEUKOSIS VIRUS; ROUS-SARCOMA VIRUS; LONG TERMINAL REPEATS; DIFFERENTIAL EXPRESSION; PROMOTER INSERTION; ONCOGENE; ACTIVATION; DNA; TRANSCRIPTION; ORGANIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
W.P. Jiang et al., "MINIMAL TRUNCATION OF THE C-MYB GENE-PRODUCT IN RAPID-ONSET B-CELL LYMPHOMA", Journal of virology, 71(9), 1997, pp. 6526-6533

Abstract

Oncogenic activation of c-myb by insertional mutagenesis has been implicated in rapid-onset B-cell lymphomas induced by the nonacute avian leukosis virus EU-8. In these tumors. proviruses are integrated eitherupstream of the c-myb coding region or within the first intron of c-myb. Tumors with either type of integration contained identical chimeric mRNAs in which the viral 5' splice site was juxtaposed to the 3' splice site of c-myb exon 2 and myb exon 1 was eliminated, Both classes of integrations generated truncated Myb proteins that were indistinguishable by Western analysis. In contrast to most other examples of c-mybactivation, the truncation consisted of only 20 N-terminal amino acids and did not disrupt either the DNA binding domain near the N terminus or the negative regulatory domain near the C terminus of Myb. The significance of tile 20-amino-acid Myb truncation to tumorigenesis was tested by infection of chicken embryos with retroviral vectors expressing different myb gene products, While virus expressing either wild-type c-myb or c-myb mutated at the N-terminal casein kinase II sites was only weakly oncogenic at 10 weeks, the minimally truncated myb virus induced a high incidence of rapid-onset tumors, including B-cell lymphomas, sarcomas, and adenocarcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:15:00