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Titolo:
ALPHA-METHYLNORADRENALINE-INDUCED CONTRACTIONS IN RAT AORTA ARE MEDIATED VIA ALPHA(1D)-ADRENOCEPTORS
Autore:
CASTILLO EF; VALENCIA I; BOBADILLA RM; VILLALON CM; CASTILLO C;
Indirizzi:
ESCUELA SUPER MED,DEPT FISIOL & FARMACOL,PLAN SAN LUIS & DIAZ MIRON,COL CASCO DE STO TOMAS MEXICO CITY 11340 17 DF MEXICO IPN,SECC TERAPEUT EXPT,DEPT FARMACOL & TOXICOL MEXICO CITY 11340 17 DF MEXICO
Titolo Testata:
Fundamental and clinical pharmacology
fascicolo: 4, volume: 11, anno: 1997,
pagine: 339 - 345
SICI:
0767-3981(1997)11:4<339:ACIRAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VAS-DEFERENS; SUBTYPES; ALPHA-1-ADRENOCEPTORS; CHLORETHYLCLONIDINE; SUBCLASSIFICATION; NORADRENALINE; HETEROGENEITY;
Keywords:
ALPHA(1D)-ADRENOCEPTORS; RAT AORTA; ALPHA-METHYLNORADRENALINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
E.F. Castillo et al., "ALPHA-METHYLNORADRENALINE-INDUCED CONTRACTIONS IN RAT AORTA ARE MEDIATED VIA ALPHA(1D)-ADRENOCEPTORS", Fundamental and clinical pharmacology, 11(4), 1997, pp. 339-345

Abstract

The subtype(s) of alpha-adrenoceptor-mediating contractions to alpha-methynoradrenaline in the rat aorta has been investigated by using alpha-adrenoceptor-selective competitive antagonists and the alpha(1)-adrenoceptor selective agonist, phenylephrine, for comparison. alpha-Methylnoradrenaline and phenylephrine elicited concentration-dependent contractions in the endothelium-denuded and endothelium-intact aortic rings with similar potencies and maximal effects. alpha-Methylnoradrenaline- and phenylephrine-induced contractions in endothelium-denuded aortic rings were competitively antagonized by prazosin (pA(2) = 9.38 and 9.13; respectively) and rauwolscine (pA(2) = 7.19 and 6.60, respectively). This confirms that there is an alpha(1)- and a non alpha(2)-adrenoceptor response to alpha-methylnoradrenaline in the rat aorta. The subtype selective alpha(1D)-adrenoceptor antagonist, BMY 7378, was foundto antagonize contractions to alpha-metbylnoradrenaline and phenylephrine competitively in endothelium-denuded and endothelium-intact aortic rings. The pA(2) values of BMY 7378 against alpha-methylnoradrenaline (8.39 and 8.41; endothelium-intact and endothelium-denuded, respectively) and phenylephrine (8.64 and 8.76; endothelium-intact and endothelium-denuded, respectively), are consistent with its published functional potency and clonal alpha(1d)-adrenoceptor binding affinity. In addition, contractions to alpha-methylnoradrenaline and phenylephrine in endothelium-denuded aortic rings, were potently inhibited by WE 4101 with pA(2) values of 9.75 and 9.25, respectively. The high pA(2) valuesfor WE 4101 indicate that the alpha(1B)-adrenoceptor subtype does notseem to participate in alpha-methylnoradrenaline (and phenylephrine) induced contractions in this artery. These results suggest that the alpha(1D)-subtype plays a determining role in rat aorta contractions induced by alpha-methylnoradrenaline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:58:58