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Titolo:
MOLECULAR-STRUCTURE OF THE MOUSE CCK-A RECEPTOR GENE
Autore:
LACOURSE KA; LAY JM; SWANBERG LJ; JENKINS C; SAMUELSON LC;
Indirizzi:
UNIV MICHIGAN,DEPT PHYSIOL ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT CELLULAR MOL BIOL PROGRAM ANN ARBOR MI 48109
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 236, anno: 1997,
pagine: 630 - 635
SICI:
0006-291X(1997)236:3<630:MOTMCR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL EXPRESSION; GASTRIN RECEPTOR; CHROMOSOMAL LOCALIZATION; CHOLECYSTOKININ RECEPTOR; HUMAN BRAIN; CLONING; PHOSPHORYLATION; GALLBLADDER; PANCREAS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Lacourse et al., "MOLECULAR-STRUCTURE OF THE MOUSE CCK-A RECEPTOR GENE", Biochemical and biophysical research communications, 236(3), 1997, pp. 630-635

Abstract

We have cloned the mouse CCK-A receptor gene (Cckar), determined its nucleotide sequence, and analyzed its expression. The receptor proteinis encoded in five exons distributed over 9 kb of genomic DNA. Intron/exon borders were determined by comparing the genomic nucleotide sequence with the mouse cDNA sequence obtained by reverse transcriptase polymerase chain reaction. RNase protection analysis of Cckar transcripts revealed the presence of a splice acceptor site 200 bp upstream of the translational start codon, indicating that the promoter is associated with a non-translated exon at an upstream site. The second coding exon contains a rarely used alternative splice site that would result in the production of a truncated, 48 amino acid protein. Cckar is widely expressed in the gastrointestinal system (pancreas, gallbladder, intestine, colon and stomach), as well as in brain and kidney. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:24:35