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Titolo:
CHOLESTASIS IN NEWBORN-INFANTS WITH PERINATAL ASPHYXIA
Autore:
VAJRO P; AMELIO A; STAGNI A; PALUDETTO R; GENOVESE E; GIUFFRE M; DECURTIS M;
Indirizzi:
UNIV NAPLES FEDERICO II,DEPT PEDIAT,VIA PANSINI 5 I-80131 NAPLES ITALY UNIV PALERMO,IST MATERNO INFANTILE PALERMO ITALY
Titolo Testata:
Acta paediatrica
fascicolo: 8, volume: 86, anno: 1997,
pagine: 895 - 898
SICI:
0803-5253(1997)86:8<895:CINWPA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL CHOLESTASIS; ISCHEMIC HEPATITIS; RAT-LIVER; DIAGNOSIS; PROGNOSIS;
Keywords:
NEONATAL CHOLESTASIS; PERINATAL ASPHYXIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
P. Vajro et al., "CHOLESTASIS IN NEWBORN-INFANTS WITH PERINATAL ASPHYXIA", Acta paediatrica, 86(8), 1997, pp. 895-898

Abstract

Objective: The aim of this study was to characterize the liver involvement in infants who have both neonatal asphyxia and neonatal cholestasis. Methods: We describe four asphyctic newborn infants (three born at term) who developed early (age 3.8 +/- 2.1 days) intrahepatic neonatal cholestasis and in whom tests for causes of neonatal liver damage were negative. Results: The clinical picture and course were benign andsimilar to that of sporadic ''idiopathic'' neonatal hepatitis. Clinical signs and abnormal liver function tests tended to normalize within the first year of life in all. Conjugated bilirubin became normal at 6months after the onset of cholestasis, while liver enzymes tended towards normal values thereafter, within 1 year of follow-up. Liver biopsy (taken in one patient) showed a typical picture of giant cell hepatitis; ultrastructure was nonspecific. Significance: Our results suggestthat isolated asphyxia should be taken into account as a potential causal factor in term or pre-term asphyctic newborns who develop early ''idiopathic'' neonatal cholestasis.

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Documento generato il 21/09/20 alle ore 15:49:36