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Titolo:
Quantitative and qualitative scintigraphic measurement of renal function in dogs exposed to toxic doses of gentamicin
Autore:
Lora-Michiels, M; Anzola, K; Amaya, G; Solano, M;
Indirizzi:
Tufts Univ, Sch Vet Med, North Grafton, MA 01536 USA Tufts Univ North Grafton MA USA 01536 et Med, North Grafton, MA 01536 USA Univ Nacl, Fac Vet Med, Santafe De Bogota, Colombia Univ Nacl Santafe De Bogota Colombia t Med, Santafe De Bogota, Colombia Clin Reina Sofia, Dept Nucl Med, Santafe De Bogota, Colombia Clin Reina Sofia Santafe De Bogota Colombia Santafe De Bogota, Colombia La Salle Univ, Fac Med Vet, Santafe De Bogota, Colombia La Salle Univ Santafe De Bogota Colombia t, Santafe De Bogota, Colombia
Titolo Testata:
VETERINARY RADIOLOGY & ULTRASOUND
fascicolo: 6, volume: 42, anno: 2001,
pagine: 553 - 561
SICI:
1058-8183(200111/12)42:6<553:QAQSMO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; TC-99M-DIETHYLENETRIAMINEPENTAACETIC ACID; TC-99M MERCAPTOACETYLTRIGLYCINE; PLASMA DISAPPEARANCE; KIDNEY-FUNCTION; CREATININE; CLEARANCE; DTPA; FLOW; CATS;
Keywords:
canine; renal scintigraphy; glomerular filtration rate; effective renal plasma flow; uptake; dimercaptosuccinic acid; mercaptoacetyltriglycine; diaminepentaacetic acid; gentamicin; renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lora-Michiels, M Duke Univ, Med Ctr, Dept Radiat Oncol, Box 3455, Durham, NC 27710 USA Duke Univ Box 3455 Durham NC USA 27710 rham, NC 27710 USA
Citazione:
M. Lora-Michiels et al., "Quantitative and qualitative scintigraphic measurement of renal function in dogs exposed to toxic doses of gentamicin", VET RAD ULT, 42(6), 2001, pp. 553-561

Abstract

Five, 3-month-old mongrel dogs weighing between 4.5 to 5.5 kg were studiedto evaluate and compare the efficiency of Tc-99m-DTPA, Tc-99m-MAG(3), and Tc-99m-DMSA in detecting gentamicin-induced renal tubular injury. After baseline renograms using all three methods, all dogs received daily intramuscular injections of gentamicin at a dose of 30-45 mg/kg. Additional studies were obtained after a cumulative dose of 450, 1,575, and 2,250 mg of gentamicin was reached. Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and percentage of total renal uptake measurements were calculated. Baseline and post-gentamicin injection blood urea nitrogen (BUN) and serum creatinine values were determined. A Duncan test revealed significant renal function impairment at 450 mgs of cumulated gentamicin with Tc-99m-DMSA and at 1,575 mgs of cumulated gentamicin for Tc-99m-DTPA and Tc-99m-MAG(3). There was no correlation between BUN and serum creatinine values when compared to gentamicin (p > 0.05). The images obtained with Tc-99m-MAG(3) were of better quality than those obtained with Tc-99m-DTPA even under severe renal dysfunction. Percentage of Tc-99m-DMSA uptake indicated renal damage,before than GFR and ERPF. BUN and serum creatinine measurements were poor indicators of gentamicin-induced renal failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:20:23